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Merck
CN

E100

Supelco

(-)-氧化毒扁豆碱 富马酸盐

analytical standard, for drug analysis

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About This Item

经验公式(希尔记法):
C13H18N2O · C4H4O4
CAS号:
分子量:
334.37
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:

等级

analytical standard, for drug analysis

质量水平

表单

solid

旋光性

[α]23/D −107.9°, c = 0.5 in methanol(lit.)

技术

HPLC: suitable
gas chromatography (GC): suitable

颜色

white

溶解性

0.1 M HCl: soluble (Solutions should be freshly prepared.)
0.1 M NaOH: soluble (Solutions should be freshly prepared.)
H2O: soluble (Solutions should be freshly prepared.)
methanol: slightly soluble (Solutions should be freshly prepared.)

应用

forensics and toxicology
pharmaceutical (small molecule)
veterinary

包装形式

neat

储存温度

2-8°C

SMILES字符串

[H]\C(=C(\[H])C(O)=O)C(O)=O.[H][C@]12N(C)CC[C@@]1(C)c3cc(O)ccc3N2C

InChI

1S/C13H18N2O.C4H4O4/c1-13-6-7-14(2)12(13)15(3)11-5-4-9(16)8-10(11)13;5-3(6)1-2-4(7)8/h4-5,8,12,16H,6-7H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t12-,13+;/m1./s1

InChI key

PBZRRADJWNBPNY-XDRMOJKASA-N

基因信息

human ... ACHE(43)

应用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

生化/生理作用

毒扁豆碱(依色林)代谢物,其在某些神经元细胞系中具有细胞毒性;它同时具有抗乙酰胆碱酯酶和阿片激动剂活性;强效镇痛药。

注意

吸湿、光敏

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Chang-Soo Han et al.
Materials (Basel, Switzerland), 12(6) (2019-03-29)
Lacosamide (LCM) is a third-generation antiepileptic drug. Selective action of the drug on voltage-gated sodium channels reduces side effects. Oral administration of LCM shows good pharmacokinetic profile. However, the bitter taste of LCM is a barrier to the development of
Javier Otero et al.
Soft matter, 14(19), 3783-3790 (2018-05-02)
We present experimental studies of two aqueous drops, stabilized by colloidal silica, which are placed close to each other in a bath of toluene, ethanol and surplus colloidal silica. If one of the drops is enriched in ethanol while the
Swapnalee Sarmah et al.
Scientific reports, 10(1), 3951-3951 (2020-03-05)
Ethanol exposure during prenatal development causes fetal alcohol spectrum disorder (FASD), the most frequent preventable birth defect and neurodevelopmental disability syndrome. The molecular targets of ethanol toxicity during development are poorly understood. Developmental stages surrounding gastrulation are very sensitive to
A Galli et al.
Biochemical pharmacology, 31(7), 1233-1238 (1982-04-01)
The action of eseroline--(3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indo l-5-ol--salicylate was tested on preparations of ChE from different sources and on the longitudinal muscle of guinea-pig ileum. While eseroline is eseroline is extremely weak-acting on horse serum BuChE (Ki = 208 +/- 42 microM), it
S M Somani et al.
Toxicology and applied pharmacology, 106(1), 28-37 (1990-10-01)
The toxic effects of physostigmine, an anticholinesterase drug, and its metabolite eseroline were investigated in three neuronal cell culture systems, mouse neuroblastoma N1E-115, rat glioma C6, and neuroblastoma-glioma hybrid NG 108-15. Physostigmine and eseroline (0.5 nM) elicited a time-dependent leakage

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