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Merck
CN

E0109000

依那普利

European Pharmacopoeia (EP) Reference Standard

别名:

依那普利 马来酸盐, ( S )-N-[1-(乙氧基羰基)-3-苯基丙基]-Ala-Pro 马来酸盐

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About This Item

经验公式(希尔记法):
C20H28N2O5 · C4H4O4
CAS号:
分子量:
492.52
UNSPSC代码:
41116107
NACRES:
NA.24

等级

pharmaceutical primary standard

API类

enalapril

制造商/商品名称

EDQM

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES字符串

C[C@@H](C(N1[C@H](C(O)=O)CCC1)=O)N[C@H](CC(OCC)=O)CCC2=CC=CC=C2.O=C(OO)/C=C\C(O)=O

InChI

1S/C21H30N2O5.C4H4O5/c1-3-28-19(24)14-17(12-11-16-8-5-4-6-9-16)22-15(2)20(25)23-13-7-10-18(23)21(26)27;5-3(6)1-2-4(7)9-8/h4-6,8-9,15,17-18,22H,3,7,10-14H2,1-2H3,(H,26,27);1-2,8H,(H,5,6)/b;2-1-/t15-,17-,18-;/m0./s1

InChI key

UQKQUZOIQFOJOI-KJHLASMFSA-N

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Enalapril maleate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

一种长效血管紧张素转换酶抑制剂。

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

象形图

Health hazard

警示用语:

Warning

危险声明

预防措施声明

危险分类

Repr. 2

WGK

WGK 2


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分析证书(COA)

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Marta de Diego et al.
Journal of chromatographic science, 52(10), 1193-1197 (2013-12-04)
A simple and rapid stability-indicating liquid chromatographic method was developed and validated for the simultaneous determination of lisinopril and hydrochlorotiazide (HCTZ) in drug substances and dosage forms in the presence of degradation products. Forced degradation studies were conducted on the
Jorge Luiz Alves-Pereira et al.
The Journal of urology, 192(6), 1878-1883 (2014-06-01)
We evaluated whether antihypertensive drugs that act through the renin-angiotensin system would affect testis function. Ten mice were fed standard chow and 40 received a high energy density diet. At 8 weeks the high energy density diet mice were divided
John J V McMurray et al.
The New England journal of medicine, 371(11), 993-1004 (2014-09-02)
We compared the angiotensin receptor-neprilysin inhibitor LCZ696 with enalapril in patients who had heart failure with a reduced ejection fraction. In previous studies, enalapril improved survival in such patients. In this double-blind trial, we randomly assigned 8442 patients with class
Neprilysin inhibition--a novel therapy for heart failure.
Mariell Jessup
The New England journal of medicine, 371(11), 1062-1064 (2014-09-02)
[Heart failure and LCZ696].
Guy Sabourin
Perspective infirmiere : revue officielle de l'Ordre des infirmieres et infirmiers du Quebec, 12(1), 61-61 (2015-02-06)

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