推荐产品
质量水平
形式
powder
效能
≥750 μg per mg (dry basis)
杂质
≤5% Kanamycin B
SMILES字符串
OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
InChI
1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
InChI key
OOYGSFOGFJDDHP-KMCOLRRFSA-N
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应用
硫酸卡那霉素是来源于卡那链霉菌的广谱氨基糖苷类抗生素。 它可用作培养基添加剂，用于在卡那霉素七叶苷叠氮琼脂上分离D群链球菌、在卡那霉素培养基上选择含有新霉素磷酸转移酶的转化植物细胞。 硫酸卡那霉素还可用作卡那霉素B抗性基因转化细胞的选择剂。 细胞培养推荐使用浓度为100 mg/mL。
生化/生理作用
作用机制：该产品通过与70S核糖体亚基结合，抑制易位并引起错误编码而起作用。
耐药机制：氨基糖苷类修饰酶（包括乙酰转移酶、磷酸转移酶、核苷酸转移酶）可以改变这种抗生素，阻止其与核糖体相互作用。
抗菌谱：硫酸卡那霉素对革兰氏阴性和革兰氏阳性菌以及支原体有效。
耐药机制：氨基糖苷类修饰酶（包括乙酰转移酶、磷酸转移酶、核苷酸转移酶）可以改变这种抗生素，阻止其与核糖体相互作用。
抗菌谱：硫酸卡那霉素对革兰氏阴性和革兰氏阳性菌以及支原体有效。
作用机制：该产品通过与70S核糖体亚基结合，抑制易位并引起错误编码而起作用。
耐药机制：氨基糖苷类修饰酶（包括乙酰转移酶、磷酸转移酶、核苷酸转移酶）可以改变这种抗生素，阻止其与核糖体相互作用。
抗菌谱：硫酸卡那霉素对革兰氏阴性和革兰氏阳性菌以及支原体有效。
耐药机制：氨基糖苷类修饰酶（包括乙酰转移酶、磷酸转移酶、核苷酸转移酶）可以改变这种抗生素，阻止其与核糖体相互作用。
抗菌谱：硫酸卡那霉素对革兰氏阴性和革兰氏阳性菌以及支原体有效。
注意
溶液在37°C下可稳定保存约5天。 水性储备溶液可在2-8℃下长期保存。
制备说明
硫酸卡那霉素以50 mg/mL溶于水，得到澄清溶液。 它几乎不溶于酒精、丙酮、氯仿、乙醚和乙酸乙酯。 1％水溶液的pH为6.5-8.5。 无菌溶液可以采用0.2μm过滤器进行无菌过滤来制备。
警示用语：
Danger
危险声明
危险分类
Repr. 1B
WGK
WGK 2
法规信息
涉药品监管产品
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