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Merck
CN

D7439

Supelco

双氢青蒿素

analytical standard, mixture of α and β isomers

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About This Item

经验公式(希尔记法):
C15H24O5
分子量:
284.35
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24

等级

analytical standard

质量水平

方案

≥97% (TLC)

表单

powder

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

C[C@H]1C(O)O[C@@]2([H])[C@@]3(OO4)[C@](CC[C@]4(C)O2)([H])[C@H](C)CC[C@]31[H]

InChI

1S/C15H24O5/c1-8-4-5-10-9(2)12(16)18-13-15(10)11(8)6-14(3,7-17-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12?,13+,14+,15+/m1/s1

InChI key

DJGUTYJDEZGRGH-NJEKVMANSA-N

一般描述

双氢青蒿素是抗疟药蒿甲醚的主要代谢产物,对恶性疟原虫的药物敏感株和耐药株均非常有效。
抗疟药;抗银屑病;抗炎剂。

应用

有关合适仪器技术的更多信息,请参考产品 分析证书。如需进一步支持,请联系技术服务。

警告

避光保存。

制备说明

艾蒿属植物提取物

象形图

FlameEnvironment

警示用语:

Danger

危险声明

危险分类

Aquatic Chronic 2 - Org. Perox. C

储存分类代码

5.2 - Organic peroxides and self-reacting hazardous materials

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Selective determination, in plasma, of artemether and its major metabolite, dihydroartemisinin, by high-performance liquid chromatography with ultraviolet detection
Thomas GC, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 583(1), 131-136 (1992)
Anne Marijon et al.
Malaria journal, 13, 501-501 (2014-12-18)
Improving management of patients suffering from cerebral malaria is needed to reduce the devastating mortality and morbidity of the disease in endemic areas. Intravenous artesunate is currently the first-line treatment, but the lack of material and skills in the field
Zenglei Wang et al.
PloS one, 9(4), e93825-e93825 (2014-04-17)
Malaria elimination/eradication campaigns emphasize interruption of parasite transmission as a priority strategy. Screening for new drugs and vaccines against gametocytes is therefore urgently needed. However, current methods for sexual stage drug assays, usually performed by counting or via fluorescent markers
Aditya S Paul et al.
Nature communications, 11(1), 3532-3532 (2020-07-17)
Asexual proliferation of the Plasmodium parasites that cause malaria follows a developmental program that alternates non-canonical intraerythrocytic replication with dissemination to new host cells. We carried out a functional analysis of the Plasmodium falciparum homolog of Protein Phosphatase 1 (PfPP1)
Lisa Evans DeWald et al.
Scientific reports, 9(1), 20199-20199 (2019-12-29)
During the Ebola virus disease (EVD) epidemic in Western Africa (2013‒2016), antimalarial treatment was administered to EVD patients due to the high coexisting malaria burden in accordance with World Health Organization guidelines. In an Ebola treatment center in Liberia, EVD patients

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