所有图片(1)
About This Item
经验公式（希尔记法）:
C13H20N2O2
CAS号:
分子量:
236.31
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
推荐产品
等级
analytical standard, for drug analysis
质量水平
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
forensics and toxicology
pharmaceutical (small molecule)
veterinary
包装形式
neat
SMILES字符串
OCC(O)CN1CCN(CC1)c2ccccc2
InChI
1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2
InChI key
PTVWPYVOOKLBCG-UHFFFAOYSA-N
一般描述
(±)-Dropropizine is an antitussive therapeutic agent that inhibits cough through the peripheral mode of action.
应用
(±)-Dropropizine may be used as a reference standard for the determination of (±)-dropropizine in pharmaceutical formulations by spectrophotometric method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Sensitive spectrophotometric method for quantitation of guaifenesin and dropropizine in their dosage forms.
Abdallah, O M.
International Journal of Analytical Chemistry (2010)
A Lavezzo et al.
Pulmonary pharmacology, 5(2), 143-147 (1992-06-01)
The mechanism of action of levodropropizine has been investigated in different models of experimentally-induced cough in guinea-pigs. In particular it has been demonstrated that the antitussive drug has a peripheral site of action by injecting the drug intracerebroventricularly (i.c.v.). In
Novel route for the resolution of both enantiomers of dropropizine by using oxime esters and supported lipases of Pseudomonas cepacia.
Salunkhe M M, et al.
Enzyme and Microbial Technology, 28(4-5), 333-338 (2001)
H Shams et al.
British journal of pharmacology, 117(5), 853-858 (1996-03-01)
1. Levodropropizine (LVDP) is an effective antitussive drug. Its effects on single-unit discharge of vagal afferent C-fibres were tested in anaesthetized cats to assess whether an inhibition of vagal C-fibres is involved in its antitussive properties. Vagal C-fibres, identified by
G Banderali et al.
The Journal of international medical research, 23(3), 175-183 (1995-05-01)
The antitussive efficacy and tolerability of dropropizine and of its enantiomer levodropropizine were evaluated in children with non-productive cough; 258 were evaluable for tolerability and 254 for efficacy. Patients randomly received either 1 mg/kg dropropizine or 2 mg/kg levodropropizine orally
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