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安全信息

D3525

Supelco

地奥司明

analytical standard

别名:

3′,5,7-三羟基-4′-甲氧基黄酮 7-芸香糖甙

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About This Item

经验公式（希尔记法）:
C28H32O15
CAS号:
520-27-4
分子量:
608.54
EC 号:
208-289-7
MDL编号:
MFCD00009772
UNSPSC代码:
41116107
PubChem化学物质编号:
329798770
NACRES:
NA.24

等级

analytical standard

质量水平

100

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

cleaning products
cosmetics
food and beverages
personal care

包装形式

neat

储存温度

2-8°C

SMILES字符串

COc1ccc(cc1O)C2=CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2

InChI

1S/C28H32O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-8,10,19,21-30,32-37H,9H2,1-2H3/t10-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1

InChI key

GZSOSUNBTXMUFQ-YFAPSIMESA-N

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应用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

生化/生理作用

Citrus flavonoid. Modification of hesperidin. Studied for its chemopreventive properties, including anti-proliferative and anti-inflammatory.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKBW6791V
MKBR0742V
MKBQ8324V
SLBC3987V
070M1260V

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How should Product D3525, Diosmin, be dissolved?

    Diosmin is soluble in DMSO at 10 mM, per following paper:Zhang, S., et al., "Flavonoids as Aryl Hydrocarbon Receptor Agonists/Antagonists: Effects of Structure and Cell Context." Environ. Health. Perspect., 111, 1877-1882 (2003).

  4. Is Product D3525, Diosmin, synthetic or from a natural source?

    Diosmin is typically isolated from a plant source (orange or lemon). This information can be found on Certificate of Origin (CofO lot-specific). The link to CofO is located on the Product Detail Page.

  5. Does Product D3525, diosmin absorb in the UV spectrum?  If so, what is the ?max?

    Yes. Diosmin has the following UV absorbance properties: λmax: 255 nm, 268 nm, 345 nm (ethanol) Extinction coefficient: EmM = 19.05, 17.78, and 19.95.Referenced from:  chemicals encyclopedia published by the Royal Society of Chemistry, 10th ed., Entry# 3300.

  6. Product D3525, Diosmin, is a rutinoside derivative. Does Sigma-Aldrich list any other rutinosides?

    Yes, we have two others:  H5254, Hesperidin and 36428, Keracynin chloride.

  7. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Joseph D Raffetto et al.
Journal of vascular surgery, 54(2), 489-496 (2011-04-19)
Saponosides (horse chestnut seed extract, escin) and flavonoids (diosmin, Daflon 500, Servier, France) exhibit venotonic properties that have been utilized in treatment of varicose veins. However, the cellular mechanisms underlying the venotonic properties of escin and diosmin are unclear. Because
Chung Sim Lim et al.
Journal of vascular surgery, 56(4), 1069-1077 (2012-06-09)
Doxycycline and micronized purified flavonoid fraction (MPFF) modulate vein wall remodeling that may be associated with hypoxia in varicose veins (VVs), vein graft stenosis, and deep venous thrombosis. We recently reported that in vitro exposure of non-VV (NVVs) and VVs
Subramani Srinivasan et al.
Chemico-biological interactions, 195(1), 43-51 (2011-11-08)
Oxidative stress has been suggested as a contributory factor in development and complication of diabetes. The aim of the study was to evaluate the effect of diosmin (DS) in oxidative stress in streptozotocin-nicotinamide (STZ-NA)-induced diabetic rats by measuring the lipid
Jacqueline M Cohen et al.
Chest, 141(2), 308-320 (2012-02-09)
Postthrombotic syndrome (PTS) is a frequent, chronic complication of DVT. The effectiveness and safety of available treatments are unknown. The objective of this study was to systematically review the literature to assess whether pharmacologic and compression therapies are effective and
Mir Tahir et al.
Alcohol (Fayetteville, N.Y.), 47(2), 131-139 (2013-02-20)
The present investigation was designed to evaluate the efficacy of diosmin against ethanol-induced hepatotoxicity in rats by modulating various mechanisms including ethanol metabolizing enzymes, generation of free radicals, imbalance in oxidant-antioxidant status, oxidative damage to membrane lipids, activation of transcription
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