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线性分子式:
(C2H5)2NCSS2CSN(C2H5)2
化学文摘社编号:
分子量:
296.54
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
202-607-8
Beilstein/REAXYS Number:
1712560
MDL number:
产品名称
双硫仑, European Pharmacopoeia (EP) Reference Standard
InChI key
AUZONCFQVSMFAP-UHFFFAOYSA-N
InChI
1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3
SMILES string
CCN(CC)C(=S)SSC(=S)N(CC)CC
grade
pharmaceutical primary standard
API family
disulfiram
manufacturer/tradename
EDQM
mp
69-71 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
Gene Information
human ... ALDH2(217)
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1 - STOT RE 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Charlotte H Jørgensen et al.
Alcoholism, clinical and experimental research, 35(10), 1749-1758 (2011-05-28)
Alcohol use disorders (AUD) involving hazardous, harmful, and addictive misuse of alcohol are widespread in most parts of the world. The aim of this study was to review the effect of disulfiram in the treatment of patients with AUD. The
Pier Paolo Pani et al.
The Cochrane database of systematic reviews, (1)(1), CD007024-CD007024 (2010-01-22)
Cocaine dependence is a disorder for which no pharmacological treatment of proven efficacy exists, advances in the neurobiology could guide future medication development. To evaluate the efficacy and the acceptability of disulfiram for cocaine dependence. We searched: PubMed, EMBASE, CINAHL
Boris Cvek et al.
Drug discovery today, 13(15-16), 716-722 (2008-06-27)
The major approach to the development of anticancer drugs involves searching for new compounds, efficient against malignancies, which are not, as yet, used clinically. This strategy is time-consuming and expensive. Recent studies have disclosed a surprising, but mechanistically consistent, anticancer
Parvinder Hothi et al.
Oncotarget, 3(10), 1124-1136 (2012-11-21)
Glioblastoma Multiforme (GBM) continues to have a poor patient prognosis despite optimal standard of care. Glioma stem cells (GSCs) have been implicated as the presumed cause of tumor recurrence and resistance to therapy. With this in mind, we screened a
Meriem Gaval-Cruz et al.
Molecular interventions, 9(4), 175-187 (2009-09-02)
The anti-alcoholism drug disulfiram (Antabuse), which is an inhibitor of aldehyde dehydrogenase, induces an aversive reaction to alcohol consumption and thereby helps patients reduce alcohol intake. Recent clinical trials, initiated to investigate whether disulfiram could be used to treat individuals
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