等级
pharmaceutical primary standard
API类
cisplatin
制造商/商品名称
EDQM
mp
270 °C (lit.)
应用
pharmaceutical (small molecule)
格式
neat
SMILES字符串
N.N.Cl[Pt]Cl
InChI
1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
InChI key
LXZZYRPGZAFOLE-UHFFFAOYSA-L
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一般描述
应用
本欧洲药典参考标准仅用于欧洲药典中明确规定的用途。不保证适用于任何其他用途,用户请自行负责。本标准品不适用于人类或动物使用。
根据欧洲药典,用于配制下列给定溶液:
根据欧洲药典,用于配制下列给定溶液:
- 鉴定参考溶液,根据各论 0559,采用红外吸收光谱法和薄层色谱法检测相关物质,使用采用液相色谱法(通则 2.2.29)检测顺铂
- 参考溶液 (b),根据各论 1081,使用液相色谱法(通则 2.2.29)检测异麦芽酮糖醇中的相关物质
生化/生理作用
强效的铂基抗肿瘤剂。与 DNA 二核苷酸 d(pGpG) 形成细胞毒性加合物,诱导链内交联。
包装
本品按照现行药典要求提供。有关当前单位数量,请见EDQM 参考目录。
其他说明
相应销售限制条件可能适用。
相关产品
产品编号
说明
价格
警示用语:
Danger
危险分类
Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Cisplatin
European pharmacopoeia, 2231-2232 (2009)
Carboplatin
European pharmacopoeia, 6104-6105 (2022)
The Lancet. Oncology, 14(8), 777-786 (2013-06-21)
The results of FASTACT, a randomised, placebo-controlled, phase 2 study, showed that intercalated chemotherapy and erlotinib significantly prolonged progression-free survival (PFS) in patients with advanced non-small-cell lung cancer. We undertook FASTACT-2, a phase 3 study in a similar patient population.
International journal of cancer, 135(7), 1692-1699 (2013-08-02)
Radiotherapy (RT) with concurrent cisplatin (CRT) is standard treatment for locally advanced cervical cancer. However, not all patients benefit from the addition of cisplatin to RT alone. This study explored the value of pretreatment tumor interstitial fluid pressure (IFP) and
Blood, 123(26), 4111-4119 (2014-05-03)
Acquired resistance to targeted drugs is emerging as an obstacle to successful cancer treatment. Recently, a BCL2-selective BH3 mimetic termed ABT-199 showed promising therapeutic results in BCL2-dependent tumors. Based on its high affinity for BCL2, we studied potential mechanisms conferring
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