等级
pharmaceutical primary standard
API类
chlorothiazide
制造商/商品名称
EDQM
应用
pharmaceutical (small molecule)
格式
neat
SMILES字符串
O=S(C1=C2C=C(Cl)C(S(N)(=O)=O)=C1)(NC=N2)=O
InChI
1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
InChI key
JBMKAUGHUNFTOL-UHFFFAOYSA-N
基因信息
human ... SLC12A3(6559)
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一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
应用
One of the first in the thiazide class of diuretics.
包装
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他说明
Sales restrictions may apply.
警示用语：
Danger
危险声明
危险分类
Resp. Sens. 1 - Skin Sens. 1
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
Krzysztof J Paluch et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 41(5), 603-611 (2010-09-08)
Chlorothiazide (CTZ), unlike other thiazide diuretics, can form salts. An injectable formulation containing the sodium salt is available; however neither the physicochemical characteristics of the salt nor its solid state form have been previously reported. This work reports on the
L P Brion et al.
The Cochrane database of systematic reviews, (1)(1), CD001454-CD001454 (2008-02-07)
Lung edema may complicate respiratory distress syndrome (RDS) in preterm infants. The aim of this review was to assess the risks and benefits of diuretic administration in preterm infants with RDS. The standard search method of the Cochrane Neonatal Review
Krzysztof J Paluch et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 42(3), 220-229 (2010-12-01)
Chlorothiazide (CTZ) is a poorly soluble diuretic agent. The aim of the present work was to produce and characterise a potassium salt form of chlorothiazide which has the potential advantages of improved aqueous solubility and potassium supplementation. A number of
Charlotte K Leech et al.
Acta crystallographica. Section B, Structural science, 64(Pt 1), 101-107 (2008-01-22)
The compounds chlorothiazide and hydrochlorothiazide (crystalline form II) have been studied in their fully hydrogenous forms by powder neutron diffraction on the GEM diffractometer. The results of joint Rietveld refinement of the structures against multi-bank neutron and single-bank X-ray powder
Khalid Hussain et al.
The Journal of clinical endocrinology and metabolism, 91(8), 2839-2842 (2006-05-11)
Congenital hyperinsulinism (CHI) is a cause of severe hypoglycemia in the neonatal and infancy period. Histologically, there are two subtypes with diffuse and focal disease. The preoperative differentiation of these two forms is very important because the surgical management is
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