InChI
1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
SMILES string
O=S(C1=C2C=C(Cl)C(S(N)(=O)=O)=C1)(NC=N2)=O
InChI key
JBMKAUGHUNFTOL-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
chlorothiazide
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
Gene Information
human ... SLC12A3(6559)
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Application
One of the first in the thiazide class of diuretics.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
Charlotte K Leech et al.
Acta crystallographica. Section B, Structural science, 64(Pt 1), 101-107 (2008-01-22)
The compounds chlorothiazide and hydrochlorothiazide (crystalline form II) have been studied in their fully hydrogenous forms by powder neutron diffraction on the GEM diffractometer. The results of joint Rietveld refinement of the structures against multi-bank neutron and single-bank X-ray powder
L P Brion et al.
The Cochrane database of systematic reviews, (1)(1), CD001454-CD001454 (2008-02-07)
Lung edema may complicate respiratory distress syndrome (RDS) in preterm infants. The aim of this review was to assess the risks and benefits of diuretic administration in preterm infants with RDS. The standard search method of the Cochrane Neonatal Review
Krzysztof J Paluch et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 41(5), 603-611 (2010-09-08)
Chlorothiazide (CTZ), unlike other thiazide diuretics, can form salts. An injectable formulation containing the sodium salt is available; however neither the physicochemical characteristics of the salt nor its solid state form have been previously reported. This work reports on the
Krzysztof J Paluch et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 42(3), 220-229 (2010-12-01)
Chlorothiazide (CTZ) is a poorly soluble diuretic agent. The aim of the present work was to produce and characterise a potassium salt form of chlorothiazide which has the potential advantages of improved aqueous solubility and potassium supplementation. A number of
Saleem Shaikh et al.
Journal of pharmaceutical and biomedical analysis, 48(3), 1055-1057 (2008-09-26)
A simple and precise high performance liquid chromatographic method has been developed and validated for the simultaneous determination of bisoprolol fumarate (BF), and hydrochlorothiazide (HCTZ) in a tablet formulation. Chromatography was carried out at 25 degrees C on a 4.6
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