推荐产品
Agency
USP/NF
meets USP testing specifications
质量水平
检测方案
97.0-103.0%
形式
crystalline
颜色
white
mp
83-86 °C (lit.)
应用
pharmaceutical (small molecule)
储存温度
2-8°C
SMILES字符串
CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C
InChI
1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
InChI key
QYSXJUFSXHHAJI-YRZJJWOYSA-N
基因信息
human ... VDR(7421)
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一般描述
胆钙化醇(维生素D3)是一种在皮肤中产生的脂溶性类固醇。
应用
胆钙化醇已被用于:
- 诱导小鼠动脉中膜钙化 (arterial medial calcification,AMC)
- 研究其在肥胖和胰岛素抵抗小鼠模型中对血管钙化(VC)相关血管重塑的影响(ob / ob小鼠)
- 研究其对单层培养物中RWPE2-W99细胞锚定依赖性生长的影响
生化/生理作用
维生素 D 借以发挥作用的受体是配体依赖性转录因子超家族的成员。调控正常细胞和癌细胞的增殖和分化。对乳腺癌、结肠癌和前列腺癌细胞具有抗增殖和抗转移作用。肠和骨骼中的活化维生素 D 受体维持着钙的吸收和平衡。
警示用语:
Danger
危险分类
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 1 Oral
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Expansive vascular remodeling and increased vascular calcification response to cholecalciferol in a murine model of obesity and insulin resistance
Arteriosclerosis, Thrombosis, and Vascular Biology, 39(2), 200-211 (2019)
Cholecalciferol (vitamin D 3) inhibits growth and invasion by up-regulating nuclear receptors and 25-hydroxylase (CYP27A1) in human prostate cancer cells
Clinical & Experimental Metastasis, 22(3), 275-284 (2005)
Runx2 expression in smooth muscle cells is required for arterial medial calcification in mice
The American Journal of Pathology, 185(7), 1958-1969 (2015)
Chronic Kidney Disease-Mineral and Bone Disorder
Handbook of Dialysis Therapy, 685-697 (2016)
Hypertension (Dallas, Tex. : 1979), 65(6), 1195-1201 (2015-03-25)
Vitamin D deficiency is a risk factor for arterial hypertension, but randomized controlled trials showed mixed effects of vitamin D supplementation on blood pressure (BP). We aimed to evaluate whether vitamin D supplementation affects 24-hour systolic ambulatory BP monitoring values
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