推荐产品
等级
drug standard
质量水平
Agency
EPA 1694
浓度
1.0 mg/mL in methanol
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
environmental
pharmaceutical (small molecule)
包装形式
single component solution
储存温度
2-8°C
SMILES字符串
CN1[C@@H](CCC1=O)c2cccnc2
InChI
1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1
InChI key
UIKROCXWUNQSPJ-VIFPVBQESA-N
基因信息
human ... CYP1A2(1544) , CYP2A6(1548)
mouse ... Cyp2a5(13087)
相关类别
一般描述
（−）-可替宁是尼古丁的主要代谢产物，广泛用作评估环境烟草烟雾暴露、戒烟验证和确定主动吸烟行为百分比的生化标志物。
应用
有关合适的仪器技术的更多信息，请参阅产品′分析证书。想要获得更多支持，请联系技术服务部。
（−）-可替宁溶液已被用作使用超高效液相色谱-质谱法（UPLC-MS）分析空气样品中尼古丁的标准品。
（−）-可替宁溶液已被用作使用超高效液相色谱-质谱法（UPLC-MS）分析空气样品中尼古丁的标准品。（−）-可替宁可作为分析标准品，通过高效液相色谱技术对生物样品中的分析物进行定量分析。
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
51.8 °F - closed cup
闪点(°C)
11 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves
法规信息
危险化学品
Rapid and sensitive high-performance liquid chromatographic determination of nicotine and cotinine in nonsmoker human and rat urines
Oddoze.C, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 708(1-2), 95-101 (1998)
A simple, sensitive, and rapid method for the determination of cotinine in urine by high-performance liquid chromatography with UV detection
Rabbaa-Khabbaz L, et al.
Journal of Chromatographic Science, 44(9), 535-538 (2006)
A sensitive HPLC-ESI-MS-MS method for the determination of cotinine in urine
Apinan R, et al.
Journal of Chromatographic Science, 48(6), 460-465 (2010)
Mohammad A Kaisar et al.
BMC neuroscience, 18(1), 71-71 (2017-10-13)
A sensitive, rapid and selective UHPLC-MS/MS method has been developed and validated for the quantification of Nicotine (NT) and Cotinine (CN) using Continine-d A linear response function was established for the range of concentrations 3-200 (r > 0.995) for NT and 3-600 ng/mL
Assessment of nicotine for second hand smoke exposure in some public places in Romania by UPLC-MS
Bratan A, et al.
Chemistry Central Journal, 8(1), 29-29 (2014)
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