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BP1115

比卡鲁胺 (CDX)

British Pharmacopoeia (BP) Reference Standard

别名:

N-[4-氰基-3-(三氟甲基)苯基]-3-(4-氟苯硫酰基)-2-甲基-2-羟基丙酰胺, 比卡他胺, 比卡胺

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About This Item

经验公式（希尔记法）:
C18H14F4N2O4S
CAS号:
90357-06-5
分子量:
430.37
MDL编号:
MFCD00869971
UNSPSC代码:
41116107
NACRES:
NA.24

等级

pharmaceutical primary standard

API类

bicalutamide

表单

solid

保质期

limited shelf life, expiry date on the label

制造商/商品名称

BP

应用

pharmaceutical
pharmaceutical small molecule

包装形式

neat

储存温度

2-8°C

SMILES字符串

CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc2ccc(C#N)c(c2)C(F)(F)F

InChI

1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)

InChI key

LKJPYSCBVHEWIU-UHFFFAOYSA-N

基因信息

human ... AR(367)

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相关类别

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Bicalutamide BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Bicalutamide Tablets

    • 生化/生理作用

    比卡鲁胺 (CDX) 是一种非杀菌的雄激素受体 (AR) 拮抗剂，是纯抗雄激素。它通过平衡组蛋白乙酰化/去乙酰化和共调剂募集发挥作用。比卡鲁胺(CDX)消除了雄激素介导的表达。例如，前列腺癌、PLZF（早幼粒细胞白血病锌指蛋白）和GADD45γ中的MMP13上调（生长停滞和可诱导的DNA损伤，γ）。通过雄激素，对PI3K /AKT磷酸化进行非基因组、非转录依赖性刺激，抑制比卡鲁胺(CDX)。
    比卡鲁胺(CDX)是一种非杀菌性雄激素受体 (AR) 拮抗剂，是一种纯雄激素抗体。

    包装

    Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    其他说明

    Sales restrictions may apply.

    象形图

    Health hazardEnvironment
    GHS08,GHS09

    警示用语：

    Danger

    危险声明

    H351,H360FD,H410

    危险分类

    Aquatic Chronic 1 - Carc. 2 - Repr. 1B

    储存分类代码

    6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

    WGK

    WGK 3

    闪点(°F)

    Not applicable

    闪点(°C)

    Not applicable

    历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number

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