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Merck
CN

B7522

Supelco

苯氟雷司 盐酸盐

analytical standard

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别名:
N-(1-甲基-2-(3-[三氟甲基]-苯基)乙基]氨基乙醇苯甲酸酯
经验公式(希尔记法):
C19H20F3NO2 · HCl
CAS号:
分子量:
387.82
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24

等级

analytical standard

质量水平

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

forensics and toxicology
pharmaceutical (small molecule)

格式

neat

SMILES字符串

Cl.CC(Cc1cccc(c1)C(F)(F)F)NCCOC(=O)c2ccccc2

InChI

1S/C19H20F3NO2.ClH/c1-14(12-15-6-5-9-17(13-15)19(20,21)22)23-10-11-25-18(24)16-7-3-2-4-8-16;/h2-9,13-14,23H,10-12H2,1H3;1H

InChI key

NLOALSPYZIIXEO-UHFFFAOYSA-N

基因信息

human ... SOAT1(6646)

一般描述

Benfluorex hydrochloride salt is a hypolipidaemic compound with lipid and glucose lowering effects.
It is used in the treatment of impaired carbohydrate metabolism, atherogenic metabolic disorders and in the suppression of appetite.

应用

Benfluorex hydrochloride may be used as a reference standard for characterization of human urinary metabolites of benfluorex by gas chromatography–electron ionization–mass spectrometry (GC-EI-MS) as well as liquid chromatography–electrospray ionization–high resolution/high accuracy tandem mass spectrometry (LC-ESI-MS/MS) method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

分析证书(COA)

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Agnès Fournier et al.
Pharmacoepidemiology and drug safety, 21(4), 343-351 (2012-02-10)
To estimate the number of deaths from valvular insufficiency caused by the use of the fenfluramine-derivative benfluorex during the period 1976-2009 in France. Our calculation was based on (i) the exposure level to benfluorex in the French population, derived from
Thermal and X-ray powder diffraction structural characterization of two benfluorex hydrochloride polymorphs.
Maccaroni E, et al.
Journal of Pharmaceutical and Biomedical Analysis, 53(1), 1-6 (2010)
Screening for benfluorex and its major urinary metabolites in routine doping controls.
Thevis M, et al.
Analytical and Bioanalytical Chemistry, 401(2), 543-551 (2011)
Nam Sook Kim et al.
Rapid communications in mass spectrometry : RCM, 35(3), e8989-e8989 (2020-10-27)
Recently, illegal dietary supplements containing unauthorized compounds have been seized and internationally publicized with a warning to avoid their consumption. This adulteration can be a serious threat to public health because of insufficient and reliable safety data as well as
Mediator scandal engulfs French compensation body.
Asher Mullard
Lancet (London, England), 381(9880), 1803-1803 (2013-05-30)

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