SMILES string
[o]1c2c(c(c1CC)C(=O)c3ccc(cc3)O)cccc2
InChI
1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3
InChI key
RFRXIWQYSOIBDI-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
benzarone
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Benzarone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
W Voelter et al.
Journal of chromatography, 290, 1-12 (1984-05-04)
Using 2-ethyl-3-(4- hydroxybenzoyl )benzofuran ( EHBB ) as an example, biotransformation in rabbits and rats and by rat hepatocyte suspensions was studied by high-performance liquid chromatography (HPLC) and mass spectrometry. The biotransformation of N-alkyl-substituted piperidines by rat hepatocytes gives valuable
J X de Vries et al.
Journal of chromatography, 382, 167-174 (1986-10-31)
Benzarone (the debrominated metabolite of the uricosuric drug benzbromarone) has been proposed for treatment of vascular disorders. An assay was developed for the quantitation of total benzarone (conjugated and unconjugated) in plasma and urine, following oral intake of benzarone. Enzymatic
[On the site of action of benzarone and some other agents influencing the intracellular concentration of cyclic nucleotides].
L O Zwillenberg et al.
Arzneimittel-Forschung, 32(9), 1114-1120 (1982-01-01)
H Iven et al.
Cancer chemotherapy and pharmacology, 21(4), 337-342 (1988-01-01)
In anesthetized rabbits, continuous infusion of methotrexate (MTX; 30 micrograms kg-1 min-1) established steady-state plasma concentrations for MTX and the metabolite 7-hydroxymethotrexate (7-OH-MTX) within 40 min. Fifty percent of the infused dose was eliminated unchanged by the kidneys and the
Subfulminant hepatitis requiring liver transplantation after benzarone administration.
M Gehenot et al.
Journal of hepatology, 20(6), 842-842 (1994-06-01)
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