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经验公式(希尔记法):
C13H18Br2N2O · HCl
化学文摘社编号:
分子量:
414.56
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
245-899-2
MDL number:
产品名称
盐酸氨溴索 盐酸盐, analytical standard
InChI key
QNVKOSLOVOTXKF-PFWPSKEQSA-N
InChI
1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H/t10-,11-;
SMILES string
Cl.Nc1c(Br)cc(Br)cc1CN[C@@H]2CC[C@@H](O)CC2
grade
analytical standard
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
storage temp.
2-8°C
Quality Level
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Application
在使用反相顺序注射色谱法 (RP-SIC) 和反相高效液相色谱法 (RP-HPLC) 测定药物制剂中盐酸氨溴索含量时,盐酸氨溴索标准品可用作参比标准品。
有关合适仪器技术的更多信息,请参考产品的分析证书。如需进一步支持,请联系技术服务部门。
Biochem/physiol Actions
溴己新代谢物。
钠通道 Nav1.8 阻断剂
钠通道 Nav1.8 阻断剂
General description
盐酸氨溴索为粘液溶解祛痰药,是溴己新的代谢产物。 用于治疗以黏稠或黏液过多时为特征的呼吸障碍。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Jauch, R., et al.
Arzneimittelforschung, 13, 474-474 (1963)
Concise Dictionary of Pharmacological Agents: Properties and Synonyms (2012)
Wolfram Gaida et al.
Neuropharmacology, 49(8), 1220-1227 (2005-09-27)
Neuropathic pain affects many patients, and treatment today is far from being perfect. Nav1.8 Na(+) channels, which are expressed by small fibre sensory neurons, are promising targets for novel analgesics. Na(+) channel blockers used today, however, show only limited selectivity
Giovanni Ciana et al.
Molecular genetics and metabolism reports, 25, 100678-100678 (2020-12-10)
Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the acid β-glucosidase encoding gene (GBA1), resulting in the deficient activity of acid β-glucosidase (GCase). To date, there is no approved treatment for the neurological manifestations
Sequential injection chromatographic determination of ambroxol hydrochloride and doxycycline in pharmaceutical preparations.
Satinsky D, et al.
Talanta, 68(2), 214-218 (2005)
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