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Merck
CN

A9797

Supelco

盐酸氨溴索 盐酸盐

analytical standard

别名:

2-氨基-3,5-二溴-N-( 反式 -4-羟基环己基)苄胺

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About This Item

经验公式(希尔记法):
C13H18Br2N2O · HCl
CAS号:
分子量:
414.56
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24

等级

analytical standard

质量水平

保质期

limited shelf life, expiry date on the label

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

forensics and toxicology
pharmaceutical (small molecule)
veterinary

格式

neat

储存温度

2-8°C

SMILES字符串

Cl.Nc1c(Br)cc(Br)cc1CN[C@@H]2CC[C@@H](O)CC2

InChI

1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H/t10-,11-;

InChI key

QNVKOSLOVOTXKF-PFWPSKEQSA-N

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一般描述

盐酸氨溴索为粘液溶解祛痰药,是溴己新的代谢产物。 用于治疗以黏稠或黏液过多时为特征的呼吸障碍。

应用

在使用反相顺序注射色谱法 (RP-SIC) 和反相高效液相色谱法 (RP-HPLC) 测定药物制剂中盐酸氨溴索含量时,盐酸氨溴索标准品可用作参比标准品。
有关合适仪器技术的更多信息,请参考产品的分析证书。如需进一步支持,请联系技术服务部门。

生化/生理作用

溴己新代谢物。
钠通道 Nav1.8 阻断剂

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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分析证书(COA)

Lot/Batch Number

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Wolfram Gaida et al.
Neuropharmacology, 49(8), 1220-1227 (2005-09-27)
Neuropathic pain affects many patients, and treatment today is far from being perfect. Nav1.8 Na(+) channels, which are expressed by small fibre sensory neurons, are promising targets for novel analgesics. Na(+) channel blockers used today, however, show only limited selectivity
Jauch, R., et al.
Arzneimittelforschung, 13, 474-474 (1963)
Sequential injection chromatographic determination of ambroxol hydrochloride and doxycycline in pharmaceutical preparations.
Satinsky D, et al.
Talanta, 68(2), 214-218 (2005)
Giovanni Ciana et al.
Molecular genetics and metabolism reports, 25, 100678-100678 (2020-12-10)
Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the acid β-glucosidase encoding gene (GBA1), resulting in the deficient activity of acid β-glucosidase (GCase). To date, there is no approved treatment for the neurological manifestations
Concise Dictionary of Pharmacological Agents: Properties and Synonyms (2012)

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