A6848
氨曲南
analytical standard
别名:
[2S-[2α,3β(Z)]]-2-[[[1-(2-氨基-4-噻唑基)-2-[(2-甲基-4-氧代-1-磺基-3-氮杂环丁烷)氨基]-2-氧代亚乙基]氨基]氧代]-2-甲基丙酸
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关于此项目
经验公式（希尔记法）:
C13H17N5O8S2
化学文摘社编号:
分子量:
435.43
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
278-839-9
MDL number:
产品名称
氨曲南, analytical standard
InChI key
WZPBZJONDBGPKJ-VEHQQRBSSA-N
InChI
1S/C13H17N5O8S2/c1-5-7(10(20)18(5)28(23,24)25)16-9(19)8(6-4-27-12(14)15-6)17-26-13(2,3)11(21)22/h4-5,7H,1-3H3,(H2,14,15)(H,16,19)(H,21,22)(H,23,24,25)/b17-8-/t5-,7-/m0/s1
SMILES string
C[C@H]1[C@H](NC(=O)\C(=N/OC(C)(C)C(O)=O)c2csc(N)n2)C(=O)N1S(O)(=O)=O
grade
analytical standard
form
powder or crystals
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
Quality Level
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Application
The analytical standard can be used as follows:
- Determination of aztreonam in two simulated lung fluid solutions― artificial lysosomal fluid and gamble solution by a UV spectroscopic method
- Multi-residue analysis of eight β-lactams by ultra-high performance liquid chromatography (UHPLC) combined with a photo-diode array (PDA) detector in human plasma & serum samples
- Simultaneous quantitative analysis of nine β-lactams by UHPLC along with tandem mass spectrometry (MS/MS) in human plasma samples
General description
Aztreonam belongs to the group of monocyclic β-lactam antibiotics, isolated from Chromobacterium violaceum. It is used against gram-negative bacterial infections, such as infections of the bladder, kidneys, bone, and urinary tract. It acts by binding to the penicillin-binding protein-3 (PBP3) and inhibiting the synthesis of bacterial cell walls causing cell lysis and death.
Other Notes
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
涉药品监管产品
此项目有
The Antimicrobial Drugs (2000)
Neonatal and Pediatric Pharmacology: Therapeutic Principles in Practice (2010)
Greg L Plosker
Drugs, 70(14), 1843-1855 (2010-09-15)
Aztreonam is a monobactam antibacterial with bactericidal activity against a wide range of aerobic Gram-negative bacteria, including Pseudomonas aeruginosa. Aztreonam lysine for inhalation solution (AZLI) does not contain the potentially inflammatory component arginine, which is used as a buffer in
Baroukh Maurice Assael
Expert review of anti-infective therapy, 9(11), 967-973 (2011-10-28)
An aerosol form of aztreonam lysinate has recently been developed as a treatment for cystic fibrosis patients suffering from chronic Pseudomonas aeruginosa lung colonization. Local administration means the drug can reach mucus concentrations in the order of hundreds of times
Céline Vidaillac et al.
Antimicrobial agents and chemotherapy, 53(6), 2360-2366 (2009-04-08)
Ceftaroline is a novel broad-spectrum cephalosporin that exhibits bactericidal activity against many gram-positive and -negative pathogens. However, the activity of ceftaroline cannot be solely relied upon for eradication of multidrug-resistant gram-negative isolates, such as Pseudomonas aeruginosa and extended-spectrum beta-lactamase (ESBL)-producing
相关内容
Product Information Sheet
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