推荐产品
产品名称
金精三羧酸 铵盐, ACS reagent
生物来源
synthetic
质量水平
等级
ACS reagent
表单
powder or crystals
技术
titration: suitable
杂质
≤0.1% insolubles
灼烧残渣
≤0.2%
颜色
dark red
mp
220-225 °C (dec.) (lit.)
溶解性
water: soluble 100 mg/mL
λmax
450 nm
522 nm (2nd)
应用
diagnostic assay manufacturing
hematology
histology
储存温度
room temp
SMILES字符串
N.N.N.OC(=O)c1cc(ccc1O)\C(c2ccc(O)c(c2)C(O)=O)=C3/C=CC(=O)C(=C3)C(O)=O
InChI
1S/C22H14O9.3H3N/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31;;;/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31);3*1H3
InChI key
AIPNSHNRCQOTRI-UHFFFAOYSA-N
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应用
铝试剂
生化/生理作用
金精三羧酸易于在水溶液中聚合，形成稳定的自由基，抑制蛋白质-核酸相互作用。它通过阻止核酸与酶的结合而成为核糖核酸酶和拓扑异构酶 II 的有效抑制剂。它刺激酪氨酸磷酸化过程，包括 NB2 淋巴瘤细胞中的 Jak2/STAT5 途径，神经母细胞瘤细胞中的 ErbB4，以及 PC12 细胞中的 MAP 激酶、Shc 蛋白、磷脂酰肌醇 3-激酶和磷脂酶 C。金精三羧酸抑制许多细胞类型的细胞凋亡。其神经保护作用，可能是由于其能够阻止 Ca2+ 不可渗透的 GluR2 受体的下调或其抑制钙蛋白酶的能力，钙蛋白酶是一种在凋亡过程中被激活的 Ca2+ 激活的蛋白酶。
其他说明
可能含有大量的聚合物材料。
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Hui-Chen Hung et al.
The Journal of antimicrobial chemotherapy, 65(4), 676-683 (2010-01-22)
Enterovirus 71 (EV71) causes serious diseases in humans. The aim of this study was to examine the effects of aurintricarboxylic acid (ATA) on EV71 replication and to explore the underlying mechanism. To measure the activity of ATA in inhibiting the
Hui-Chen Hung et al.
Antiviral research, 81(2), 123-131 (2008-11-19)
There is a continuing threat that the highly pathogenic avian influenza virus will cause future influenza pandemics. In this study, we screened a library of compounds that are biologically active and structurally diverse for inhibitory activity against influenza neuraminidase (NA).
Jakyung Yoo et al.
Advances in protein chemistry and structural biology, 87, 219-247 (2012-05-23)
DNA methyltransferases (DNMTs) are promising epigenetic targets for the development of novel anticancer drugs and other diseases. Molecular modeling and experimental approaches are being used to identify and develop inhibitors of human DNMTs. Most of the computational efforts conducted so
Moonhee Lee et al.
Neurobiology of aging, 34(5), 1451-1461 (2012-11-28)
Aberrant complement activation is known to exacerbate the pathology in a spectrum of degenerative diseases of aging. We previously reported that aurin tricarboxylic acid (ATA) is an orally effective agent which prevents formation of the membrane attack complex of complement.
Munmun Bardhan et al.
Journal of photochemistry and photobiology. B, Biology, 102(1), 11-19 (2010-09-25)
In this paper, the nature of the interactions between bovine serum albumin (BSA) and aurintricarboxylic acid (ATA) has been investigated by measuring steady state and time-resolved fluorescence, circular dichroism (CD), FT-IR and fluorescence anisotropy in protein environment under physiological conditions.
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