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主要文件

A0152000

乙酰半胱氨酸杂质C

European Pharmacopoeia (EP) Reference Standard

别名:

N,N′-二乙酰基-L-胱氨酸, NSC 203780

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About This Item

经验公式(希尔记法):
C10H16N2O6S2
CAS号:
分子量:
324.37
EC 号:
MDL编号:
UNSPSC代码:
41116107
NACRES:
NA.24

等级

pharmaceutical primary standard

API类

acetylcysteine

制造商/商品名称

EDQM

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

S(SCC(NC(=O)C)C(=O)O)CC(NC(=O)C)C(=O)O

InChI

1S/C10H16N2O6S2/c1-5(13)11-7(9(15)16)3-19-20-4-8(10(17)18)12-6(2)14/h7-8H,3-4H2,1-2H3,(H,11,13)(H,12,14)(H,15,16)(H,17,18)

InChI key

YTPQSLLEROSACP-UHFFFAOYSA-N

一般描述

本品按现行药典规定交付。所有为支持本产品而提供的信息,包括 SDS 和任何产品信息小册子,均由药典颁发机构制定和发布。

如需进一步信息和支持,请访问现行药典网站。

应用

本欧洲药典参考标准仅用于欧洲药典中明确规定的用途。不保证适用于任何其他用途,用户请自行负责。本标准品不适用于人类或动物使用。
用于制备参考溶液 (c),根据欧洲药典各论 0967,使用气相色谱法(通则 2.2.28)测试乙酰半胱氨酸中的相关物质。

包装

本品按照现行药典要求提供。有关当前单位数量,请见EDQM 参考目录

其他说明

可能适用相应的销售限制。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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B Särnstrand et al.
The Journal of pharmacology and experimental therapeutics, 288(3), 1174-1184 (1999-02-23)
Oral N-acetyl-L-cysteine (NAC) is used clinically for treatment of chronic obstructive pulmonary disease. NAC is easily oxidized to its disulfide. We show here that N,N'-diacetyl-L-cystine (DiNAC) is a potent modulator of contact sensitivity (CS)/delayed type hypersensitivity (DTH) reactions in rodents.
Pei Wang et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 39(10), 782-786 (2005-02-11)
To study the therapeutic effects of N,N'-diacetyl-L-cystine (DiNAC) on immunological liver failure. Serum ALT, AST and T cell subsets in peripheral blood of the experimental animals during the trial period were analyzed by an automatic serum analyzer and a flow
Knut S Pettersson et al.
Basic & clinical pharmacology & toxicology, 100(1), 36-42 (2007-01-12)
N,N-diacetyl-L-cystine (DiNAC), a novel immunomodulator, stimulates contact sensitivity/delayed type hypersensitivity reactions in mice induced by oxazolone and reduces atherosclerosis in Watanabe heritable hyperlipidaemic (WHHL) rabbits. Forty-week-old WHHL rabbits were given DiNAC (3 micromol/kg per day) for 8 weeks, and endothelium-mediated
S Boräng et al.
Gene, 271(2), 183-192 (2001-06-22)
In this study, we have applied and evaluated a modified cDNA representational difference analysis (RDA) protocol based on magnetic bead technology to study the molecular effects of a candidate drug (N,N'-diacetyl-L-cystine, DiNAC) in a model for atherosclerosis. Alterations in a
S Böhler et al.
Infusionstherapie (Basel, Switzerland), 15(2), 89-92 (1988-04-01)
In this study the question of whether N-N-diacetylcystine (DAC), which is more stable than N-acetylcysteine (AcCYS), may provide a useful cysteine source for parenteral nutrition was investigated. In in vitro studies the release of cysteine from DAC was measured. The

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