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Merck
CN

94873

4-羟基他莫西芬

(E) and (Z) isomers (50:50), analytical standard

别名:

4-(1-[4-(二甲基氨基乙氧基)苯基]-2-苯基-1-丁烯)苯酚, 4-OHT, 顺/反-4-羟基三苯氧胺

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关于此项目

经验公式（希尔记法）:
C26H29NO2
化学文摘社编号:
68392-35-8
分子量:
387.51
NACRES:
NA.24
UNSPSC Code:
41116107

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InChI

1S/2C26H29NO2/c2*1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h2*5-17,28H,4,18-19H2,1-3H3/b26-25+;26-25-

InChI key

ZJLDABGSDWXVGE-BDSXMVAQSA-N

SMILES string

CC\C(c1ccccc1)=C(/c2ccc(O)cc2)c3ccc(OCCN(C)C)cc3.CC\C(c4ccccc4)=C(\c5ccc(O)cc5)c6ccc(OCCN(C)C)cc6

grade

analytical standard

assay

≥97.5% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

impurities

≤5.0% water

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

Quality Level

100

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相关类别

General description

4-羟基他莫昔芬是第一代选择性雌激素受体调节剂（SERM），在乳腺癌细胞中起拮抗剂作用，但在子宫和骨骼中可表现出雌激素样活性。

Application

4-羟基他莫昔芬可用作参考标准品，通过高效液相色谱法（HPLC）和荧光检测测定血浆样品中的4-羟基他莫昔芬。
有关合适的仪器技术的更多信息，请参阅产品′的检验报告。想要获得更多支持，请联系技术服务部。

Biochem/physiol Actions

化疗药物他莫昔芬的代谢物，表现出比母体药物更有效的雌激素激动剂/拮抗剂活性。也具有脂质过氧化的膜内抑制剂的活性。

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN7662
BCCM1474
BCCL8996
BCCG4506
BCCG8443

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