92688
5,5-二甲基-1-吡咯啉-N-氧化物
for ESR-spectroscopy
别名:
DMPO
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关于此项目
经验公式（希尔记法）:
C6H11NO
化学文摘社编号:
分子量:
113.16
UNSPSC Code:
41115710
NACRES:
NA.21
PubChem Substance ID:
EC Number:
222-011-1
Beilstein/REAXYS Number:
107603
MDL number:
产品名称
5,5-二甲基-1-吡咯啉-N-氧化物, for ESR-spectroscopy
SMILES string
CC1(C)CCC=[N+]1[O-]
InChI key
VCUVETGKTILCLC-UHFFFAOYSA-N
InChI
1S/C6H11NO/c1-6(2)4-3-5-7(6)8/h5H,3-4H2,1-2H3
assay
≥98.0% (GC)
form
crystals
refractive index
n20/D 1.496 (lit.)
bp
75 °C/0.4 mmHg (lit.)
mp
25-29 °C (lit.)
density
1.015 g/mL at 25 °C (lit.)
storage temp.
−20°C
Quality Level
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Application
5,5-二甲基-1-吡咯啉-N-氧化物是在吡咯烷衍生物的合成过程中通常用作自由基自旋捕获剂或亲电子组分的试剂。它也被认为是环加成过程中的1,3-偶极子。
神经保护剂；一氧化氮自旋捕获剂。用于研究通过酶促乙醛氧化反应形成的自由基。
神经保护剂；一氧化氮自旋捕获剂。用于研究通过酶促乙醛氧化反应形成的自由基。用DMPO孵育淋巴细胞，可减少NiCl2对DNA的损伤。
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
203.0 °F - closed cup
flash_point_c
95 °C - closed cup
Karim Michail et al.
Analytical chemistry, 84(15), 6739-6746 (2012-06-26)
Free radicals are conventionally detected by electron paramagnetic resonance (EPR) spectroscopy after being trapped as spin adducts. Albeit this technique has demonstrated utmost efficacy in studying free radicals, its application to biological settings is intrinsically hampered by the inevitable bioreduction
Murugesan Velayutham et al.
Free radical biology & medicine, 51(1), 160-170 (2011-05-07)
In cells, mitochondria, endoplasmic reticulum, and peroxisomes are the major sources of reactive oxygen species (ROS) under physiological and pathophysiological conditions. Cytochrome c (cyt c) is known to participate in mitochondrial electron transport and has antioxidant and peroxidase activities. Under
Ronald P Mason
Free radical biology & medicine, 36(10), 1214-1223 (2004-04-28)
The detection of protein free radicals using the specific free radical reactivity of nitrone spin traps in conjunction with nitrone-antibody sensitivity and specificity greatly expands the utility of the spin trapping technique, which is no longer dependent on the quantum
Pedro L Zamora et al.
The journal of physical chemistry. A, 116(26), 7210-7218 (2012-06-07)
Radical forms of sulfur dioxide (SO(2)), sulfite (SO(3)(2-)), sulfate (SO(4)(2-)), and their conjugate acids are known to be generated in vivo through various chemical and biochemical pathways. Oxides of sulfur are environmentally pervasive compounds and are associated with a number
Patrick T Kang et al.
Free radical biology & medicine, 53(4), 962-973 (2012-05-29)
Complex I is a critical site of O(2)(•-) production and the major host of reactive protein thiols in mitochondria. In response to oxidative stress, complex I protein thiols at the 51- and 75-kDa subunits are reversibly S-glutathionylated. The mechanism of
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