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Merck
CN
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安全信息

917850

Sigma-Aldrich

tert-Butyl 4-(2-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate

≥95%

别名:

Semi-flexible linker for PROTAC® development

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About This Item

经验公式（希尔记法）:
C18H27NO3
CAS号:
170837-78-2
分子量:
305.41
MDL编号:
MFCD30099263
UNSPSC代码:
12352116

质量水平

100

检测方案

≥95%

形式

powder

反应适用性

reagent type: linker

官能团

Boc
hydroxyl

储存温度

2-8°C

SMILES字符串

O=C(N(CC1)CCC1C2=C(CCO)C=CC=C2)OC(C)(C)C

应用

tert-Butyl 4-(2-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

其他说明

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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象形图

Exclamation markEnvironment
GHS07,GHS09

警示用语：

Warning

危险分类

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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