2-(2-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride

2-(2-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license