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Merck
CN
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安全信息

917354

Sigma-Aldrich

tert-Butyl 4-(4-(aminomethyl)phenyl)piperidine-1-carboxylate

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别名:
Semi-flexible linker for PROTAC® development
经验公式（希尔记法）:
C17H26N2O2
CAS号:
1198286-87-1
分子量:
290.40
MDL编号:
MFCD09038246
UNSPSC代码:
12352200

形式

powder

质量水平

100

反应适用性

reagent type: linker

官能团

Boc
amine

储存温度

2-8°C

SMILES字符串

O=C(N(CC1)CCC1C(C=C2)=CC=C2CN)OC(C)(C)C

应用

tert-Butyl 4-(4-(aminomethyl)phenyl)piperidine-1-carboxylate is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

其他说明

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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