909815
4-Azido-L-homoalanine hydrochloride
≥98%
别名:
(S)-2-Amino-4-azidobutanoic acid hydrochloride, 4-Azido-L-homoalanine HCl, 4-Azido-L-homoalanine hydrochloride, H-L-Aha-OH*HCl
InChI key
MHHYJRIDKLZZEO-DFWYDOINSA-N
InChI
1S/C4H8N4O2.ClH/c5-3(4(9)10)1-2-7-8-6;/h3H,1-2,5H2,(H,9,10);1H/t3-;/m0./s1
assay
≥98%
form
powder
reaction suitability
reaction type: solution phase peptide synthesis
manufacturer/tradename
(BCAA-005)
availability
available only in USA
storage temp.
2-8°C
Application
The in vivo incorporation of clickable unnatural amino acids such as 4-Azido-L-homoalanine with unique reactivity at a defined postition is used for functionalization of proteins. The azide functionalities in the protein can then be modified with almost any alkyne bearing molecule by Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). Copper-free alternatives with strained internal alkynes are also available (SPAAC). Some examples enabled with this technique are protein PEGylation, masking with sugars, and the attachment to antibodies.
signalword
Danger
hcodes
Hazard Classifications
Self-react. C
存储类别
5.2 - Organic peroxides and self-reacting hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Jigang Wang et al.
Nature protocols, 12(2), 279-288 (2017-01-13)
At present, several assays that use radioisotope labeling to quantify the degradation of long-lived proteins have been developed to measure autophagic flux. Here, we describe a nonradioactive pulse-chase protocol using L-azidohomoalanine (AHA) labeling to quantify long-lived protein degradation during autophagy.
Milena Ullrich et al.
Nature protocols, 9(9), 2237-2255 (2014-08-29)
In this protocol we describe the incorporation of bio-orthogonal amino acids as a versatile method for visualizing and identifying de novo-synthesized proteins in the roundworm Caenorhabditis elegans. This protocol contains directions on implementing three complementary types of analysis: 'click chemistry'
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