推荐产品
表单
powder
反应适用性
reaction type: click chemistry
储存温度
−20°C
SMILES字符串
P(N(C(C)C)C(C)C)(OC1[C@H](O[C@H](C1)N2C=C(C(=O)NC2=O)C#CCCCCC#C)COC([3H])[2H])OCCC#N
InChI
1S/C27H39N4O6P/c1-7-8-9-10-11-12-14-22-18-30(27(33)29-26(22)32)25-17-23(24(36-25)19-34-6)37-38(35-16-13-15-28)31(20(2)3)21(4)5/h1,18,20-21,23-25H,8-11,13,16-17,19H2,2-6H3,(H,29,32,33)/t23?,24-,25-,38?/m1/s1/i6TD/t6?,23?,24-,25-,38?
InChI key
VMEOYXBOBQPPSL-YSJOBRKDSA-N
应用
This functional phosphoramidite is used to introduce click handles univerally (5′ internal and 3′end) into oligonucleotides under standard conditions for solid phase synthesis. Afterwards the oligonucleotide (RNA, PNA, DNA) can be efficiently conjugated using a copper-catalyzed click reaction to azide-functionalized moieties such as fluorescent dye azides and azido amino acids
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Chemistry & biodiversity, 3(5), 509-514 (2006-12-29)
The synthesis of a series of oligonucleotides containing 5-substituted pyrimidines as well as 7-substituted 7-deazapurines bearing diyne groups with terminal triple bonds is reported. The modified nucleosides were prepared from the corresponding iodo nucleosides and diynes by the Sonogashira cross-coupling
DNA photography: an ultrasensitive DNA-detection method based on photographic techniques.
Angewandte Chemie (International ed. in English), 46(22), 4184-4187 (2007-04-27)
Chembiochem : a European journal of chemical biology, 8(16), 1997-2002 (2007-09-15)
This paper describes a straightforward procedure to immobilize oligonucleotides on glass substrates in well-defined micropatterns by microcontact printing with a dendrimer-modified stamp. The oligonucleotides are efficiently immobilized by "click" chemistry induced by microcontact printing. Acetylene-modified oligonucleotides were treated with an
Organic letters, 8(17), 3639-3642 (2006-08-11)
[reaction: see text] We report the development of the Cu(I)-catalyzed Huisgen cycloaddition (click) reaction for the multiple postsynthetic labeling of alkyne-modified DNA. A series of alkyne-modified oligodeoxyribonucleotides (ODNs) of increasing alkyne density were prepared, and the click reaction using various
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