90833
3-羧基-4-甲基-5-丙基-2-呋喃丙酸
analytical standard
别名:
3-羧基-4-甲基-5-丙基-2-呋喃丙酸, CMPF, 丙基呋喃酸
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关于此项目
经验公式（希尔记法）:
C12H16O5
化学文摘社编号:
分子量:
240.25
UNSPSC Code:
12352106
NACRES:
NB.21
MDL number:
InChI
1S/C12H16O5/c1-3-4-8-7(2)11(12(15)16)9(17-8)5-6-10(13)14/h3-6H2,1-2H3,(H,13,14)(H,15,16)
SMILES string
OC(CCC1=C(C(O)=O)C(C)=C(CCC)O1)=O
InChI key
WMCQWXZMVIETAO-UHFFFAOYSA-N
grade
analytical standard
assay
≥95.0% (HPLC)
shelf life
limited shelf life, expiry date on the label
application(s)
clinical testing
format
neat
storage temp.
2-8°C
Quality Level
General description
3-羧基-4-甲基-5-丙基-2-呋喃丙酸（CMPF）是呋喃脂肪酸的主要代谢产物，是一种尿毒症毒素（UT），在生理条件下通过有机阴离子转运蛋白排泄到尿液中。据报道多在慢性肾脏疾病（CKD）患者体内蓄积。监测CMPF对于预测CKD患者的有机阴离子转运多肽（OATP）1B活性可能很重要，因为研究表明患有这种尿毒症毒素的患者的（OATP）1B活性呈下降趋势。对于从糖尿病前期进展为2型糖尿病的患者，患有肾衰的患者，高温烹饪的多不饱和脂肪酸和食用鱼或鱼油的受试者，也发现其浓度增加。
Application
3-羧基-4-甲基-5-丙基-2-呋喃丙酸可作为分析标准品，通过高效液相色谱-串联质谱联用（UHPLC-MS/MS）对人血浆样品中的分析物进行定量分析。
存储类别
11 - Combustible Solids
wgk
WGK 3
Simultaneous quantification of coproporphyrin-I and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid in human plasma using ultra-high performance liquid chromatography coupled to tandem mass spectrometry
Suzuki Y, et al.
Journal of Pharmaceutical and Biomedical Analysis (2020)
Furan fatty acids?Beneficial or harmful to health
Xu L, et al.
Progress in Lipid Research, 68, 119-137 (2017)
Increased serum 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) levels are associated with glucose metabolism in Chinese pregnant women
Yi J, et al.
Journal of Endocrinological Investigation, 41(6), 663-670 (2018)
Metabolomics: beyond biomarkers and towards mechanisms.
Johnson, C.H., et al.
Nature Reviews in Molecular and Cell Biology, 17, 451-459 (2016)
Nicolas Fabresse et al.
Clinica chimica acta; international journal of clinical chemistry, 507, 228-235 (2020-05-07)
The objectives of this study were (1) to develop a method for the determination of 10 uremic toxins (3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), hippuric acid, indole-3-acetic acid, indoxyl sulfate, kynurenic acid, kynurenine, p-cresyl glucuronide, p-cresyl sulfate, phenylacetylglutamine and trimethylamine N-oxide (TMAO)), and
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