推荐产品
等级
analytical standard
质量水平
检测方案
≥95.0% (HPLC)
保质期
limited shelf life, expiry date on the label
应用
clinical testing
格式
neat
储存温度
2-8°C
SMILES字符串
OC(CCC1=C(C(O)=O)C(C)=C(CCC)O1)=O
InChI
1S/C12H16O5/c1-3-4-8-7(2)11(12(15)16)9(17-8)5-6-10(13)14/h3-6H2,1-2H3,(H,13,14)(H,15,16)
InChI key
WMCQWXZMVIETAO-UHFFFAOYSA-N
相关类别
一般描述
3-羧基-4-甲基-5-丙基-2-呋喃丙酸（CMPF）是呋喃脂肪酸的主要代谢产物，是一种尿毒症毒素（UT），在生理条件下通过有机阴离子转运蛋白排泄到尿液中。据报道多在慢性肾脏疾病（CKD）患者体内蓄积。监测CMPF对于预测CKD患者的有机阴离子转运多肽（OATP）1B活性可能很重要，因为研究表明患有这种尿毒症毒素的患者的（OATP）1B活性呈下降趋势。对于从糖尿病前期进展为2型糖尿病的患者，患有肾衰的患者，高温烹饪的多不饱和脂肪酸和食用鱼或鱼油的受试者，也发现其浓度增加。
应用
3-羧基-4-甲基-5-丙基-2-呋喃丙酸可作为分析标准品，通过高效液相色谱-串联质谱联用（UHPLC-MS/MS）对人血浆样品中的分析物进行定量分析。
WGK
WGK 3
Metabolomics: beyond biomarkers and towards mechanisms.
Johnson, C.H., et al.
Nature Reviews in Molecular and Cell Biology, 17, 451-459 (2016)
Furan fatty acids?Beneficial or harmful to health
Xu L, et al.
Progress in Lipid Research, 68, 119-137 (2017)
Increased serum 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) levels are associated with glucose metabolism in Chinese pregnant women
Yi J, et al.
Journal of Endocrinological Investigation, 41(6), 663-670 (2018)
Simultaneous quantification of coproporphyrin-I and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid in human plasma using ultra-high performance liquid chromatography coupled to tandem mass spectrometry
Suzuki Y, et al.
Journal of Pharmaceutical and Biomedical Analysis (2020)
Nicolas Fabresse et al.
Clinica chimica acta; international journal of clinical chemistry, 507, 228-235 (2020-05-07)
The objectives of this study were (1) to develop a method for the determination of 10 uremic toxins (3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), hippuric acid, indole-3-acetic acid, indoxyl sulfate, kynurenic acid, kynurenine, p-cresyl glucuronide, p-cresyl sulfate, phenylacetylglutamine and trimethylamine N-oxide (TMAO)), and
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