90568
Fenofibric acid
analytical standard
别名:
2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropionic acid, Fenofibric acid
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关于此项目
经验公式（希尔记法）:
C17H15ClO4
化学文摘社编号:
分子量:
318.75
UNSPSC Code:
77101502
NACRES:
NA.24
PubChem Substance ID:
EC Number:
255-626-9
Beilstein/REAXYS Number:
2058973
MDL number:
产品名称
Fenofibric acid, analytical standard
SMILES string
O=C(C1=CC=C(OC(C)(C)C(O)=O)C=C1)C2=CC=C(Cl)C=C2
InChI
1S/C17H15ClO4/c1-17(2,16(20)21)22-14-9-5-12(6-10-14)15(19)11-3-7-13(18)8-4-11/h3-10H,1-2H3,(H,20,21)
InChI key
MQOBSOSZFYZQOK-UHFFFAOYSA-N
grade
analytical standard
assay
≥98.0% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
impurities
≤1.0% water
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Quality Level
Gene Information
human ... PPARA(5465)
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Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Fenofibric acid may be used as a reference standard in the determination of fenofibric acid in samples of human plasma using high performance liquid chromatography (HPLC) and liquid chromatography coupled with tandem mass spectrometry (LC-MS-MS).
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
存储类别
11 - Combustible Solids
wgk
WGK 3
Simultaneous determination of rosuvastatin and fenofibric acid in human plasma by LC?MS/MS with electrospray ionization: assay development, validation and application to a clinical study.
Trivedi K R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 39(3-4), 661-669 (2005)
Determination of bezafibrate, ciprofibrate and fenofibric acid in human plasma by high-performance liquid chromatography.
Masnatta D L, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 687(2), 437-442 (1996)
Martial Caillaud et al.
Cancers, 13(1) (2021-01-02)
Paclitaxel-induced peripheral neuropathy (PIPN) is a major adverse effect of this chemotherapeutic agent that is used in the treatment of a number of solid malignancies. PIPN leads notably to burning pain, cold and mechanical allodynia. PIPN is thought to be
Roger K Verbeeck et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 18(1), 61-67 (2015-04-17)
The therapeutic equivalence of multiple registered fenofibrate formulations, several of which are suprabioavailable and therefore marketed at lower dosage strengths than their reference products, is based on the results of bioequivalence studies. Most of these formulations show a higher bioavailability
Yunxia Lu et al.
Biochemical and biophysical research communications, 458(1), 1-7 (2015-01-17)
Fenofibrate (FF) is widely used to lower blood lipids in clinical practice, but whether its protective effect on endothelium-dependent vasodilatation (EDV) in thoracic aorta is related with endoplasmic reticulum (ER) stress remains unknown. In this study, female Sprauge Dawley rats
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