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等级
analytical standard
质量水平
检测方案
≥98.5% (HPLC)
技术
HPLC: suitable
gas chromatography (GC): suitable
mp
292 °C (dec.) (lit.)
应用
food and beverages
格式
neat
SMILES字符串
[H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@]5(CC[C@@]34C)C(O)=O)[C@@]1(C)CC[C@H](O)C2(C)C
InChI
1S/C30H48O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)/t18-,19+,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
InChI key
WCGUUGGRBIKTOS-GPOJBZKASA-N
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一般描述
熊果酸属于三萜类化合物，广泛存在于草药、食品和其他植物中。它可能具有药理活性，如心脏保护、镇痛、强心、镇静和滋补作用。
应用
有关合适仪器技术的更多信息，请参考产品′s分析证书。如需进一步支持，请联系技术服务。
生化/生理作用
三萜类化合物存在于苹果等各类水果中，它是一种心脏保护剂和抗肿瘤剂。由于它能够抑制淀粉样蛋白β和CD36受体之间的相互作用，因此在研究中被用作潜在的阿尔茨海默氏病治疗剂。
WGK
WGK 3
闪点(°F)
580.5 °F
闪点(°C)
304.7 °C
个人防护装备
Eyeshields, Gloves, type N95 (US)
Pharmacology of oleanolic acid and ursolic acid
Liu J
Journal of Ethnopharmacology, 49, 57-68 (1995)
Jin-Feng Hu et al.
Journal of natural products, 69(1), 118-120 (2006-01-31)
One new (1) and four known (2-5) ursene triterpenes with potent inhibition of the formation of the bacterial biofilm Pseudomonas aeruginosa PA01 were obtained from Diospyros dendo using a high-throughput natural products chemistry procedure. These compounds were isolated as mass-limited
Huang-Yao Tu et al.
Bioorganic & medicinal chemistry, 17(20), 7265-7274 (2009-09-18)
Twenty-three ursolic acid (1) derivatives 2-24 including nine new 1 derivatives 5, 7-11, 20-22 were synthesized and evaluated for cytotoxicities against NTUB1 cells (human bladder cancer cell line). Compounds 5 and 17 with an isopropyl ester moiety at C-17-COOH and
Hao Zhang et al.
International journal of pharmaceutics, 441(1-2), 261-268 (2012-12-01)
It has been demonstrated that ursolic acid (UA) could effectively induces apoptosis of cancer cells by inhibiting the expression of cyclooxygenase 2 (COX-2), which constitutively expresses in gastric cancer. However, the hydrophobicity of UA increases the difficulty in its potential
MinKyun Na et al.
Journal of natural products, 69(11), 1572-1576 (2006-11-28)
Inhibition of protein tyrosine phosphatase-1B (PTP1B) has been proposed as a therapy for treatment of type-2 diabetes and obesity. Bioassay-guided fractionation of an EtOAc-soluble extract of the root bark of Erythrina mildbraedii, using an in vitro PTP1B inhibitory assay, resulted
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