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应用
Girard′s reagent T may be used as a derivatizing reagent for the determination of 5-Formyl-2′-deoxyuridine in cellular DNA samples using liquid chromatography–tandem mass spectrometry (LC–MS/MS) technique. Reducing saccharides can be derivatized by Girard′s reagent T and this can be analyzed by matrix-assisted laser desorption/ionization coupled to time of flight mass spectrometry (MALDI-TOF-MS) technique.
特点和优势
- Girard′s reagent T is a chemical derivatization reagent for LC-MS.
- It has carbonyl functional group possessing high proton (cation) affinity that stabilizes a positive charge.
- It is commonly used in the derivatization of nucleosides.
- Derivatization reactions in mass spectrometry are used to improve ionization efficiency.
- Derivatization can enhance precise quantitative analysis for profiling of relatively small analyte molecules, particularly in metabolomics.
法律信息
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Oksana Lavrynenko et al.
Journal of lipid research, 54(8), 2265-2272 (2013-07-12)
Ecdysteroids are potent developmental regulators that control molting, reproduction, and stress response in arthropods. In developing larvae, picogram quantities of individual ecdysteroids and their conjugated forms are present along with milligrams of structural and energy storage lipids. To enhance the
Applications of MALDI-TOF Spectroscopy (2014)
Haizheng Hong et al.
Analytical chemistry, 79(1), 322-326 (2006-12-30)
Nucleoside 5-formyl-2'-deoxyuridine (FodU) is a major thymidine lesion generated by reactive oxygen species. In vitro and in vivo replication studies revealed that FodU can be mutagenic. A reliable and sensitive quantification method is, therefore, important for assessing the biological implications
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