等级
analytical standard
质量水平
检测方案
≥98.5% (HPLC)
保质期
limited shelf life, expiry date on the label
技术
HPLC: suitable
gas chromatography (GC): suitable
杂质
≤1.0% water
应用
forensics and toxicology
pharmaceutical (small molecule)
格式
neat
储存温度
2-8°C
SMILES字符串
COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O
InChI
1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
InChI key
HPNSFSBZBAHARI-RUDMXATFSA-N
基因信息
human ... IMPDH1(3614) , IMPDH2(3615)
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一般描述
霉酚酸是酯前药霉酚酸酯（MPM）的一种活性代谢产物，其可用作免疫抑制剂以防止器官移植排斥并用于某些自身免疫性疾病的治疗。
应用
产自短密青霉的霉酚酸（MPA）是肌苷单磷酸脱氢酶的一种选择性抑制剂，从而能够抑制T和B淋巴细胞中的DNA合成。 它还可作为免疫抑制剂，并在人淋巴和单核细胞系中作为单核细胞分化和诱导的诱导剂。 MPA作为一种选择剂可用于经转染而表达了大肠杆菌黄嘌呤-鸟嘌呤磷酸核糖基转移酶基因的动物细胞，其推荐用量为25μg/mL。
有关合适仪器技术的更多信息，请参考产品分析证书。如需进一步支持，请联系技术服务。
霉酚酸可作为参考标准品，通过超高效液相色谱联用串联质谱对人体血浆中的分析物进行测定。
生化/生理作用
作用方式：本品通过抑制细胞因子诱导的一氧化氮生成，抑制嘌呤核苷酸的早期生物合成，并作为 IMP 脱氢酶的特异性抑制剂发挥作用。
注意
供应后，本品应在 2-8°C 干燥条件下储存，适当储存时可保持稳定 5 年。
制备说明
麦考酚酸可溶于 50 mg/mL 甲醇，产生无色至淡黄色溶液，以及氯仿、二氯甲烷、乙醇和 1 N 氢氧化钠溶液。复溶后，建议通过 0.22 μm 过滤器灭菌m 孔径过滤器，分装，-20°C 冷冻。
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 2 - Repr. 1B - STOT RE 1 Oral
靶器官
Immune system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
LC- MS/MS method for quantitation of mycophenolic acid, mycophenolic acid acyl-glucuronide, and 7-O-mycophenolic acid glucuronide in serum.
Merrigan SD, et al.
Clinical mass spectrometry, 3, 41- 48 (2017)
Determination of mycophenolic acid in human plasma by ultra performance liquid chromatography tandem mass spectrometry.
Upadhyay V, et al.
Journal of Pharmaceutical Analysis, 4(3), 205- 216 (2014)
Brenda C M de Winter et al.
Expert opinion on drug metabolism & toxicology, 3(2), 251-261 (2007-04-13)
Treatment with the immunosuppressive agent mycophenolate mofetil (MMF) decreases the risk of rejection after renal transplantation and improves graft survival compared with azathioprine. The exposure to the active metabolite mycophenolic acid (MPA) is correlated to the risk of developing acute
Yifan Wang et al.
Nature communications, 11(1), 5258-5258 (2020-10-18)
Macrophages play an essential role in the early immune response against Toxoplasma and are the cell type preferentially infected by the parasite in vivo. Interferon gamma (IFNγ) elicits a variety of anti-Toxoplasma activities in macrophages. Using a genome-wide CRISPR screen
Neal M Davies et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 22(9), 2440-2448 (2007-06-15)
Patient and graft survival following renal transplantation have improved markedly over the past decade, meaning that physician attention has turned more towards minimizing short- and long-term toxicities associated with immunosuppressive regimens. Gastrointestinal (GI) adverse events are common following renal transplantation
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