81619
四氢嘧啶
≥95.0% (HPLC)
别名:
(S)-2-甲基-1,4,5,6-四氢嘧啶-4-羧酸, 刺激物（B）
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关于此项目
经验公式（希尔记法）:
C6H10N2O2
化学文摘社编号:
分子量:
142.16
UNSPSC Code:
24112111
NACRES:
NA.21
PubChem Substance ID:
EC Number:
431-910-1
Beilstein/REAXYS Number:
7288977
MDL number:
产品名称
四氢嘧啶, ≥95.0% (HPLC)
InChI key
WQXNXVUDBPYKBA-YFKPBYRVSA-N
InChI
1S/C6H10N2O2/c1-4-7-3-2-5(8-4)6(9)10/h5H,2-3H2,1H3,(H,7,8)(H,9,10)/t5-/m0/s1
SMILES string
CC1=N[C@@H](CCN1)C(O)=O
assay
≥95.0% (HPLC)
form
powder
mol wt
142.16 g/mol
storage condition
dry at room temperature
color
white
solubility
methanol: soluble 10 mg/mL, clear, colorless to almost colorless
Quality Level
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Application
该 四氢嘧啶的实际应用包括酶稳定、 抗炎处理、神经退行性疾病预防和其他 治疗用途。
Biochem/physiol Actions
四氢嘧啶可用作酶稳定剂，在温度变化下维持水化和减少酶变性。还可提高双链DNA的高温稳定性。
General description
四氢嘧啶(Ectoine)， 全称4,5,6-四氢-2-甲基-4-嘧啶羧酸， 是一种两性氨基酸衍生物，作为相容性渗透保护溶质， 由好氧型、化能异养型和嗜盐性细菌生产， 抵抗渗透压胁迫、辐射和其他不利的 环境条件。
Other Notes
酶和生物大分子的稳定剂
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Adam Bownik et al.
Arhiv za higijenu rada i toksikologiju, 67(4), 260-265 (2016-12-30)
Ectoine is a compatible water molecule-binding solute (osmoprotectant) produced by several bacterial species in response to osmotic stress and unfavourable environmental conditions. This amino acid derivative can accumulate inside cells at high concentrations without interfering with natural processes and can
M.D. Vangala et al.
Bioforum, 23, 760-760 (2000)
Jens Smiatek et al.
Biophysical chemistry, 160(1), 62-68 (2011-10-22)
We have performed Molecular Dynamics simulations of ectoine, hydroxyectoine and urea in explicit solvent. Special attention has been spent on the local surrounding structure of water molecules. Our results indicate that ectoine and hydroxyectoine are able to accumulate more water
Alexander S Reshetnikov et al.
Extremophiles : life under extreme conditions, 15(6), 653-663 (2011-10-06)
The genes of ectoine biosynthesis pathway were identified in six species of aerobic, slightly halophilic bacteria utilizing methane, methanol or methylamine. Two types of ectoine gene cluster organization were revealed in the methylotrophs. The gene cluster ectABC coding for diaminobutyric
Ulrich Sydlik et al.
The European respiratory journal, 41(2), 433-442 (2012-10-27)
The life span of neutrophilic granulocytes has a determining impact on the intensity and duration of neutrophil driven lung inflammation. Based on the compatible solute ectoine, we aimed to prevent anti-apoptotic reactions in neutrophils triggered by the inflammatory microenvironment in
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