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一般描述
聚乙二醇(PEG)是一种由乙二醇形成的线性聚醚。这种非离子型高分子可溶于水、苯、乙醇、乙腈和二氯甲烷。不溶于乙醚和己烷。通常溶于单体和水相。
应用
聚乙二醇的各种用途：
- 溶解NEO2734（BET和CBP/EP300抑制剂），用于体内药效研究
- 作为组蛋白去乙酰化酶(HDAC)抑制剂ACY-1215的药物载体
- 研究药物诱导的周围神经病变作用
生化/生理作用
聚乙二醇(PEG)在药业中应用广泛。这种聚合物具有防腐作用，在生物医药领域可用于药物递送体系、生物传感和组织工程等。PEG还用于化妆品软膏、乳膏。在化工等行业中可用作粘合剂和分散剂。
特点和优势
- 环境优化型
- 生物相容性
- 独特的溶剂
WGK
WGK 1
闪点(°F)
428.0 °F
闪点(°C)
220.00 °C
个人防护装备
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Although targeting oxidative phosphorylation (OXPHOS) is a rational anticancer strategy, clinical benefit with OXPHOS inhibitors has yet to be achieved. Here we advanced IACS-010759, a highly potent and selective small-molecule complex I inhibitor, into two dose-escalation phase I trials in patients with
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Polymers and polymeric hybrids for targeted drug delivery
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Polyethylene glycol/surfactant mixtures improve lung function after HCl and endotoxin lung injuries.
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Addition of nonionic polymers such as polyethylene glycol (PEG) and dextran ameliorates inactivation of Survanta by a variety of substances in vitro. Addition of polymers to Survanta also improves pulmonary function when used to treat rats with lung injury caused
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