80073
α-Hydroxymetoprolol
analytical standard
别名:
3-[4-(1-Hydroxy-2-methoxyethyl)phenoxy]-1-isopropylamino-2-propanol, 4-{2-Hydroxy-3-[(1-methylethyl)amino]propoxy}-α-(methoxymethyl)-benzenemethanol
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所有图片(2)
About This Item
经验公式（希尔记法）:
C15H25NO4
CAS号:
分子量:
283.36
Beilstein:
6571082
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
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等级
analytical standard
质量水平
方案
≥98.0% (HPLC)
保质期
limited shelf life, expiry date on the label
技术
HPLC: suitable
gas chromatography (GC): suitable
mp
68-74 °C
应用
forensics and toxicology
pharmaceutical (small molecule)
包装形式
neat
SMILES字符串
OC(CNC(C)C)COC1=CC=C(C(O)COC)C=C1
InChI
1S/C15H25NO4/c1-11(2)16-8-13(17)9-20-14-6-4-12(5-7-14)15(18)10-19-3/h4-7,11,13,15-18H,8-10H2,1-3H3
InChI key
OFRYBPCSEMMZHR-UHFFFAOYSA-N
应用
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Ksenia Goryachkina et al.
European journal of clinical pharmacology, 64(3), 275-282 (2007-11-29)
To investigate the influence of paroxetine on metoprolol concentrations and its effect in patients treated for acute myocardial infarction (AMI) who are routinely given paroxetine as a co-treatment of depression. We recruited 17 depressed AMI patients who received metoprolol as
H Shimizu et al.
Arzneimittel-Forschung, 42(6), 802-806 (1992-06-01)
The maximum plasma concentrations (Cmax) after oral administration of 120 mg tablets of slow-release metoprolol (CAS 37350-58-6) to 75 Japanese healthy male volunteers and 15 arrhythmic patients were measured. Extensive and poor metabolizers after oral administrations of slow-release metoprolol tablets
K Balmér et al.
Journal of chromatography, 553(1-2), 391-397 (1991-08-16)
The two enantiomers of metoprolol and the four enantiomeric forms of alpha-hydroxymetoprolol were separated by liquid chromatography on a Chiralcel OD column containing a cellulose tris(3,5-dimethyl-phenylcarbamate) chiral stationary phase. The column efficiency was strongly dependent on the flow-rate and the
S W Ellis et al.
The Biochemical journal, 316 ( Pt 2), 647-654 (1996-06-01)
Cytochrome P-450 2D6 (CYP2D6) is an important human drug-metabolizing enzyme responsible for the oxidation of more than 30 widely used therapeutic agents. The enzymes encoded by the published genomic [Kimura, Umeno, Skoda, Meyer and Gonzalez (1989) Am. J. Hum. Genet.
Carrie A Morris et al.
Antimicrobial agents and chemotherapy, 58(10), 5900-5908 (2014-07-30)
The objectives of this study were to characterize any drug-drug interaction between the antimalarial Pyramax (pyronaridine-artesunate [PA]) and the CYP2D6 probe substrate metoprolol and to assess the safety of 60-day or 90-day PA redosing, particularly with regard to liver biochemistry
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