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Merck
CN

78780

Sigma-Aldrich

异硫氰酸苯酯

for HPLC derivatization, the detection of alcohols and amines, ≥99.0%

别名:

PITC

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About This Item

线性分子式:
C6H5NCS
CAS号:
分子量:
135.19
Beilstein:
471392
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.21

质量水平

方案

≥99.0%

表单

liquid

质量

for HPLC derivatization, the detection of alcohols and amines

折射率

n20/D 1.649
n20/D 1.6515 (lit.)

沸点

218 °C (lit.)

mp

−21 °C (lit.)

溶解性

water: insoluble

密度

1.13 g/mL at 20 °C
1.132 g/mL at 20 °C (lit.)

储存温度

2-8°C

SMILES字符串

S=C=Nc1ccccc1

InChI

1S/C7H5NS/c9-6-8-7-4-2-1-3-5-7/h1-5H

InChI key

QKFJKGMPGYROCL-UHFFFAOYSA-N

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一般描述

异硫氰酸苯酯是芳香族异硫氰酸酯。 它参与醇的脱水反应。它被广泛用于合成各种生物学上重要的杂环化合物。

应用

异硫氰酸苯酯可用作衍生化试剂,用于体液中各种苯丙胺衍生物的高效液相色谱(HPLC)分析。
用于伯胺和仲胺的衍生化试剂。用于通过 Edman 降解法进行多肽测序以及通过 HPLC 进行氨基酸分析。

注意

在氩气下存放

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警示用语:

Danger

危险分类

Acute Tox. 3 Oral - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

190.4 °F - closed cup

闪点(°C)

88 °C - closed cup

个人防护装备

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

法规信息

危险化学品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Determination of phenylisothiocyanate derivatives of amphetamine and its analogues in biological fluids by HPLC-APCI-MS or DAD.
Bogusz MJ, et al.
Journal of Analytical Toxicology, 21(1), 59-69 (1997)
One-pot dehydrations using phenyl isothiocyanate.
Majetich G, et al.
Tetrahedron Letters, 56(23), 3326-3329 (2015)
Amin Zolali et al.
Combinatorial chemistry & high throughput screening, 17(7), 610-613 (2014-03-19)
An efficient, one-pot and three-component synthesis of biologically important heterocyclic compounds is described from the reaction of primary amines and phenyl isothiocyanate in the presence of acryloyl chloride at room temperature without the need to use any catalyst.
Tomoyuki Oe et al.
Rapid communications in mass spectrometry : RCM, 24(2), 173-179 (2009-12-17)
This manuscript describes the results of a preliminary experiment performed as 'proof of concept' of a novel approach to absolute quantitation of proteins without the use of standard proteins. Absolute quantitation remains a challenging issue in the proteomics field. Therefore
Akira Murakami et al.
BioFactors (Oxford, England), 30(1), 1-11 (2008-01-17)
Osteoclastogenesis is induced by differentiation of hemopoietic cells of monocyte-macrophage lineage into bone-resorbing osteoclasts. The process is initiated by receptor activator of NF-kappaB ligand (RANKL) and resultant activation of mitogen-activated protein kinases (MAPK), including extracellular signal-regulated kinase (ERK)1/2, as well

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