所有图片(2)
别名:
3,4-二氢-3-甲基-4-氧代咪唑并[5,1-d]-1,2,3,5-四嗪-8-甲酰胺, 3-甲基-4-氧代-3,4-二氢咪唑并[5,1-d][1,2,3,5]四嗪-8-甲酰胺, 4-甲基-5-氧代-2,3,4,6,8-五氮杂双环[4.3.0]壬基-2,7,9-三烯-9-甲酰胺, 8-氨甲酰-3-甲基咪唑[5,1-d]-1,2,3,5-四嗪-4(3H)-酮, NSC 362856
经验公式（希尔记法）:
C6H6N6O2
推荐产品
等级
analytical standard
质量水平
产品线
VETRANAL®
检测方案
≥99.0% (HPLC)
保质期
limited shelf life, expiry date on the label
技术
HPLC: suitable
gas chromatography (GC): suitable
灼烧残渣
≤0.2%
缺失
≤0.5% loss on drying
应用
forensics and toxicology
pharmaceutical (small molecule)
veterinary
格式
neat
储存温度
2-8°C
SMILES字符串
CN1N=Nc2c(ncn2C1=O)C(N)=O
InChI
1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
InChI key
BPEGJWRSRHCHSN-UHFFFAOYSA-N
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一般描述
替莫唑胺（TMZ）是一种咪唑并四嗪衍生物的烷化剂，显示出针对鼠肿瘤的广谱抗肿瘤活性。
应用
TMZ可作为一种参考标准品通过胶束电动毛细管色谱（MEKC）对血清和脑肿瘤、液相色谱-电喷雾-串联质谱（LC-ESI-MS/MS）对水相溶液、带有MS/MS的高效液相色谱（HPLC）对活性药物成分（API）以及配备有光电二极管阵列（PDA）检测器的HPLC对药物剂型中的替莫唑胺进行分析。
有关合适仪器技术的更多信息，请参考产品′s分析证书。如需进一步支持，请联系技术服务。
法律信息
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Development and Validation of Simultaneous Detrmination of Anastrozole and Temozolomide in Pharmaceutical Dosage Forms.
Daphal VN, et al.
International Journal of Theoretical & Applied Sciences, 4(23), 48-55 (2012)
Determination of temozolomide in serum and brain tumor with micellar electrokinetic capillary chromatography.
Andrasi M, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 879(23), 2229-2233 (2011)
Stability of sample solution as a crucial point during HPLC determination of chemical purity of temozolomide drug substance
Jedynak L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 83(23), 19-27 (2013)
High-performance liquid chromatographic analysis and stability of anti-tumor agent temozolomide in human plasma.
Kim H, et al.
Journal of Pharmaceutical and Biomedical Analysis, 24(3), 461-468 (2001)
Multianalyte determination of 24 cytostatics and metabolites by liquid chromatography-electrospray-tandem mass spectrometry and study of their stability and optimum storage conditions in aqueous solution.
Negreira N, et al.
Talanta, 116(23), 290-299 (2013)
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