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等级
analytical standard
质量水平
方案
≥93.0% (HPLC)
旋光性
[α]/D -15±2°, c = 0.1 in methanol
保质期
limited shelf life, expiry date on the label
应用
clinical testing
包装形式
neat
储存温度
−20°C
SMILES字符串
[O-]C(C([H])([H])[C@](OC(/C([H])=C([H])/C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=O)([H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=O
一般描述
trans-2-Dodecenoyl-L-carnitine belongs to the class of medium-chain acylcarnitines. Acyl-L-carnitines are mostly produced from L-carnitine, which plays an important role in fatty acid metabolic pathways. It acts as a carrier of long-chain acyl groups from activated fatty acids across the inner mitochondrial membrane into the mitochondrial matrix where they undergo β-oxidation to acetyl CoA to obtain usable energy via the citric acid cycle.
trans-2-Dodecenoyl-L-carnitine, belongs to the class of acylcarnitines. It serves as a specific diagnostic metabolite biomarker, which increases in very-long-chain acyl CoA dehydrogenase (VLCAD) deficiency, determined in biological samples.
应用
trans-2-Dodecenoyl-L-carnitine may be used as an analytical reference standard for the quantification of the analyte in biological fluids of horses with atypical myopathy using gas chromatography coupled to mass spectrometry. It may also be used as an analytical standard to quantify the analyte in biological samples of patients with continuous ambulatory peritoneal dialysis (CAPD) or automated peritoneal dialysis (APD) using high-performance liquid chromatography/tandem quadrupole mass spectrometry (HPLC-TQMS).
trans-2-Dodecenoyl-L-carnitine may be used as an analytical reference standard for the quantification of the analyte in biological samples of horses with atypical myopathy using gas chromatography-mass spectrometry (GC−MS). It may also be used as an analytical standard to quantify the analyte in biological samples of patients with continuous ambulatory peritoneal dialysis (CAPD) or automated peritoneal dialysis (APD) using high-performance liquid chromatography/tandem quadrupole mass spectrometry (HPLC-TQMS).
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Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Acylcarnitines-old actors auditioning for new roles in metabolic physiology
McCoin SC, et al.
Nature reviews. Endocrinology, 11(10), 617-617 (2015)
Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy
Westermann MC, et al.
Neuromuscular Disorders, 18(5), 355-364 (2008)
Acylcarnitine esters profiling of serum and follicular fluid in patients undergoing in vitro fertilization
Varnagy A, et al.
Reproductive Biology and Endocrinology, 11(1), 67-67 (2013)
Current methods for determination of L-carnitine and acylcarnitine
Moder M, et al.
Monatshefte fur Chemie / Chemical Monthly, 136(8), 1279-1291 (2005)
L-Carnitine status in end-stage renal disease patients on automated peritoneal dialysis
Liberato DL , et al.
Journal of Nephrology, 27(6), 699-706 (2014)
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