所有图片(1)
别名:
(2R)-3-Carboxy-N,N,N-trimethyl-2-[[(2E)-1-oxo-2-dodecen-1-yl]oxy]-1-propanaminium inner salt, C12:1-Carnitine
经验公式（希尔记法）:
C19H35NO4
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等级
analytical standard
质量水平
检测方案
≥93.0% (HPLC)
旋光性
[α]/D -15±2°, c = 0.1 in methanol
保质期
limited shelf life, expiry date on the label
应用
clinical testing
格式
neat
储存温度
−20°C
SMILES字符串
[O-]C(C([H])([H])[C@](OC(/C([H])=C([H])/C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=O)([H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=O
一般描述
trans-2-Dodecenoyl-L-carnitine belongs to the class of medium-chain acylcarnitines. Acyl-L-carnitines are mostly produced from L-carnitine, which plays an important role in fatty acid metabolic pathways. It acts as a carrier of long-chain acyl groups from activated fatty acids across the inner mitochondrial membrane into the mitochondrial matrix where they undergo β-oxidation to acetyl CoA to obtain usable energy via the citric acid cycle.
trans-2-Dodecenoyl-L-carnitine, belongs to the class of acylcarnitines. It serves as a specific diagnostic metabolite biomarker, which increases in very-long-chain acyl CoA dehydrogenase (VLCAD) deficiency, determined in biological samples.
应用
trans-2-Dodecenoyl-L-carnitine may be used as an analytical reference standard for the quantification of the analyte in biological fluids of horses with atypical myopathy using gas chromatography coupled to mass spectrometry. It may also be used as an analytical standard to quantify the analyte in biological samples of patients with continuous ambulatory peritoneal dialysis (CAPD) or automated peritoneal dialysis (APD) using high-performance liquid chromatography/tandem quadrupole mass spectrometry (HPLC-TQMS).
trans-2-Dodecenoyl-L-carnitine may be used as an analytical reference standard for the quantification of the analyte in biological samples of horses with atypical myopathy using gas chromatography-mass spectrometry (GC−MS). It may also be used as an analytical standard to quantify the analyte in biological samples of patients with continuous ambulatory peritoneal dialysis (CAPD) or automated peritoneal dialysis (APD) using high-performance liquid chromatography/tandem quadrupole mass spectrometry (HPLC-TQMS).
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WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy
Westermann MC, et al.
Neuromuscular Disorders, 18(5), 355-364 (2008)
Acylcarnitine esters profiling of serum and follicular fluid in patients undergoing in vitro fertilization
Varnagy A, et al.
Reproductive Biology and Endocrinology, 11(1), 67-67 (2013)
Current methods for determination of L-carnitine and acylcarnitine
Moder M, et al.
Monatshefte fur Chemie / Chemical Monthly, 136(8), 1279-1291 (2005)
Acylcarnitines-old actors auditioning for new roles in metabolic physiology
McCoin SC, et al.
Nature reviews. Endocrinology, 11(10), 617-617 (2015)
L-Carnitine status in end-stage renal disease patients on automated peritoneal dialysis
Liberato DL , et al.
Journal of Nephrology, 27(6), 699-706 (2014)
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