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Merck
CN

73177

2,4-二硝基氟苯

derivatization grade (HPLC), LiChropur, ≥99.0% (GC)

别名:

2,4-二硝基-1-氟苯, DNFB, DNPF, FDNB, 桑格试剂

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关于此项目

线性分子式:
(O2N)2C6H3F
化学文摘社编号:
分子量:
186.10
UNSPSC Code:
23151817
NACRES:
NA.22
PubChem Substance ID:
EC Number:
200-734-3
Beilstein/REAXYS Number:
398632
MDL number:
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产品名称

2,4-二硝基氟苯, derivatization grade (HPLC), LiChropur, ≥99.0% (GC)

InChI

1S/C6H3FN2O4/c7-5-2-1-4(8(10)11)3-6(5)9(12)13/h1-3H

SMILES string

[O-][N+](=O)c1ccc(F)c(c1)[N+]([O-])=O

InChI key

LOTKRQAVGJMPNV-UHFFFAOYSA-N

grade

derivatization grade (HPLC)

assay

≥99.0% (GC)

form

(Solid or Semi-Solid or Chunk(s) or Paste or Liquid)

quality

LiChropur

technique(s)

HPLC: suitable

color

light yellow to very dark green-yellow, and Light Green to Very Dark Green

refractive index

n20/D 1.569 (lit.)

bp

178 °C/25 mmHg (lit.)

mp

25-27 °C (lit.)

density

1.482 g/mL at 25 °C (lit.)

Quality Level

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Application

1-氟-2,4-二硝基苯可作为衍生化试剂,用于高效液相色谱技术测定人血浆样品、药物制剂中的加巴喷丁和药物制剂中的盐酸美金刚。

General description

1-氟-2,4-二硝基苯是一种颜色标记剂,主要用于检测伯胺和仲胺。

Other Notes

探索最适于 HPLCLC-MS 分析的 LiChropur 试剂

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazardExclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 - STOT SE 3

target_organs

Respiratory system

存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

327.2 °F

flash_point_c

164 °C

法规信息

危险化学品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Optimization of an HPLC method for determination of gabapentin in dosage forms through derivatization with 1-fluoro-2, 4-dinitrobenzene
Souri E, et al.
Chemical & Pharmaceutical Bulletin, 55(10), 1427-1430 (2007)
A stability-indicating HPLC method for the determination of memantine hydrochloride in dosage forms through derivatization with 1-fluoro-2, 4-dinitrobenzene
Jalalizadeh H, et al.
Scientia Pharmaceutica, 82(2), 265-280 (2014)
Validated HPLC method for the determination of gabapentin in human plasma using pre-column derivatization with 1-fluoro-2, 4-dinitrobenzene and its application to a pharmacokinetic study
Jalalizadeh H, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 854(1-2), 43-47 (2007)
Morten M Nielsen et al.
Journal of immunology (Baltimore, Md. : 1950), 192(7), 2975-2983 (2014-03-07)
Substances that penetrate the skin surface can act as allergens and induce a T cell-mediated inflammatory skin disease called contact hypersensitivity (CHS). IL-17 is a key cytokine in CHS and was originally thought to be produced solely by CD4(+) T
Sonia Schuepbach-Mallepell et al.
The Journal of allergy and clinical immunology, 132(6), 1348-1357 (2013-08-21)
Innate immune sensors control key cytokines that regulate T-cell priming and T-cell fate. This is particularly evident in allergic reactions, which represent ideal systems to study the interplay of innate and adaptive immunity. In patients with contact dermatitis, inflammasome-mediated IL-1

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