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Merck
CN

70162

Sigma-Aldrich

萘啶酸

≥99.0% (T)

别名:

1,4-二氢-1-乙基-7-甲基-1,8-萘啶-4-酮-3-羧酸, 1-乙基-1,4-二氢-7-甲基-4-氧代-1,8-萘啶-3-羧酸

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About This Item

经验公式(希尔记法):
C12H12N2O3
CAS号:
分子量:
232.24
Beilstein:
750515
EC 号:
MDL编号:
UNSPSC代码:
12352200

方案

≥99.0% (T)

mp

227-229 °C (lit.)
228-230 °C

溶解性

chloroform: 20 mg/mL, clear

作用机制

DNA synthesis | interferes
enzyme | inhibits

SMILES字符串

CCN1C=C(C(O)=O)C(=O)c2ccc(C)nc12

InChI

1S/C12H12N2O3/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14/h4-6H,3H2,1-2H3,(H,16,17)

InChI key

MHWLWQUZZRMNGJ-UHFFFAOYSA-N

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一般描述

Chemical structure: quinolone

其他说明

细菌 DNA 合成抑制剂

替代产品

产品编号
说明
价格

象形图

Health hazardExclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral - Carc. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type N95 (US)

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Studies on the mode of action of nalidixic acid.
A M Pedrini et al.
European journal of biochemistry, 25(2), 359-365 (1972-02-15)
George X Song-Zhao et al.
Mucosal immunology, 7(4), 763-774 (2013-11-28)
Polymorphisms in the intracellular pattern recognition receptor gene NLRP3 (NLR family, pyrin domain containing 3) have been associated with susceptibility to Crohn's disease, a type of inflammatory bowel disease. Following tissue damage or infection, NLRP3 triggers the formation of inflammasomes
Christopher M Parry
Transactions of the Royal Society of Tropical Medicine and Hygiene, 98(7), 413-422 (2004-05-13)
Multidrug-resistant (MDR) Salmonella Typhi (resistant to chloramphenicol, ampicillin, and trimethoprim-sulphamethoxazole) and isolates with reduced susceptibility to fluoroquinolones (indicated by resistance to nalidixic acid, NaR) have caused epidemics and become endemic in southern Viet Nam during the 1990s. Short courses of
Fumie Adachi et al.
The Science of the total environment, 444, 508-514 (2013-01-08)
Fluoroquinolones (FQs) have been detected in aquatic environments in several countries. Long-term exposure to low levels of antimicrobial agents provides selective pressure, which might alter the sensitivity of bacteria to antimicrobial agents in the environment. Here, we examined FQ levels
Drug therapy reviews: nalidixic acid.
R Gleckman et al.
American journal of hospital pharmacy, 36(8), 1071-1076 (1979-08-01)

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