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Merck
CN

69864

莫能菌素 钠盐

~90% (TLC)

别名:

莫能菌素A 钠盐

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关于此项目

经验公式（希尔记法）:
C36H61NaO11
化学文摘社编号:
22373-78-0
分子量:
692.85
EC Number:
244-941-7
UNSPSC Code:
12352203
PubChem Substance ID:
24885987
Beilstein/REAXYS Number:
4122200
MDL number:
MFCD00077826

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InChI key

XOIQMTLWECTKJL-BEMBKCOJSA-M

InChI

1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40;/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40);/q;+1/p-1/t19-,20-,21+,22+,23-,24-,25-,26+,27+,28-,29+,30-,31+,33-,34-,35?,36-;/m0./s1

SMILES string

[H][C@]1([C@@]2(CC)O[C@]([C@@]3(C)OC4(C[C@H](O)[C@@H](C)[C@@]([H])([C@@H](C)[C@@H](OC)[C@@H](C([O-])=O)C)O4)CC3)([H])CC2)[C@@H](C)C[C@]([H])([C@@]5([H])O[C@@](O)(CO)[C@H](C)C[C@@H]5C)O1.[Na+]

assay

~90% (TLC)

optical activity

[α]20/D +61±2°, c = 1% in DMF

storage temp.

2-8°C

General description

Chemical structure: polyether

Other Notes

Monensin - a perturbant of cellular physiology; Forms stable complexes with monovalent cations, thus rendering those ions soluble in organic solvents, review; Transport of monovalent cations across specific biological membranes and liquid membranes; Can be used in a specific ion electrode, and to concentrate solutes against their concentration gradients.; In studies on a sodium ion gradient, as energy source for Peptostreptococcus asaccharolyticus

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - STOT RE 2

target_organs

Heart,muscle

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

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P.W. Ledger et al.
Trends in Biochemical Sciences, 9, 313-313 (1984)
G Wohlfarth et al.
Archives of microbiology, 142(2), 128-135 (1985-07-01)
The determination of enzymatic activities in cell-free extracts of Acidaminococcus fermentans and Peptostreptococcus asaccharolyticus led to a refined scheme for the pathway of glutamate fermentation via (R)-2-hydroxyglutarate to acetate and butyrate. From the ratio of these products the amount of
R Sandeaux et al.
Biochimica et biophysica acta, 684(1), 127-132 (1982-01-04)
Transmembrane 22Na fluxes across bimolecular lipid membranes are measured under two different experimental conditions: (a) the pH is the same in the two bulk aqueous solutions on either side of the membrane while the concentrations of Na+ are different; (b)
G.R. Painter
Metal Ions in Biological Systems, 19, 229-229 (1985)
Gerald Wischer et al.
Archives of animal nutrition, 67(3), 219-234 (2013-05-18)
The objective of the study was to investigate the effects of monensin on silage fermentation and microbial net protein synthesis. In Experiment 1, monensin (0.5, 1, 2, 4, 6, or 10 µg) was added to syringes that contained 120 mg
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