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等级
analytical standard
质量水平
方案
≥97.5% (HPLC)
保质期
limited shelf life, expiry date on the label
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
pharmaceutical
包装形式
neat
储存温度
2-8°C
SMILES字符串
O=C(N)N1C(C=C(O)C=C2)=C2C=CC3=C1C=CC=C3
InChI
1S/C15H12N2O2/c16-15(19)17-13-4-2-1-3-10(13)5-6-11-7-8-12(18)9-14(11)17/h1-9,18H,(H2,16,19)
InChI key
QQCFBZCATDIWTH-UHFFFAOYSA-N
一般描述
3-Hydroxycarbamazepine is a metabolite of carbamazepine, which is classified under the family of anticonvulsant drugs prevalently utilized for the therapeutic purpose. Carbamazepines occur abundantly in the environment and are suspected to cause potential threats to humans and wildlife.
应用
3-Hydroxycarbamazepine may be used as an analytical standard for the determination of the analyte in environmental samples, biological samples, water, sediment, fish (Gasterosteus aculeatus) and mollusk (Dreissena polymorpha) by various chromatography techniques.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
储存分类代码
13 - Non Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
P Pienimäki et al.
Journal of chromatography. B, Biomedical applications, 673(1), 97-105 (1995-11-03)
An HPLC assay for carbamazepine or oxcarbazepine (OXC) and six of their metabolites in one run was applied to 35 clinical samples from patients receiving monotherapy. This rapid and economical method, utilizing a simple one-step extraction with methyl tert.-butyl ether
Liquid chromatography-electrospray mass spectrometry determination of carbamazepine, oxcarbazepine and eight of their metabolites in human plasma
Breton H, et al.
Journal of Chromatography. B, Biomedical Applications, 828(1-2), 80-90 (2005)
Xiu-Sheng Miao et al.
Analytical chemistry, 75(15), 3731-3738 (2003-10-24)
A quantitative method is described for solid-phase extraction (SPE) followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the simultaneous analysis of carbamazepine and its five metabolites, 10,11-dihydro-10,11-epoxycarbamazepine, 10,11-dihydro-10,11-dihydroxycarbamazepine, 2-hydroxycarbamazepine, 3-hydroxycarbamazepine, and 10,11-dihydro-10-hydroxycarbamazepine. An SPE procedure was used to concentrate target
Gaëlle Daniele et al.
Environmental science and pollution research international, 24(20), 16893-16904 (2017-06-03)
The aims of this work are to develop suitable analytical methods to determine the widely used anticonvulsant carbamazepine and 12 of its degradation/transformation products in water, sediment, fish (Gasterosteus aculeatus) and mollusc (Dreissena polymorpha). Protocols based on solid phase extraction
R Mandrioli et al.
Journal of chromatography. B, Biomedical sciences and applications, 762(2), 109-116 (2001-10-27)
A high-performance liquid chromatographic method with UV detection for the simultaneous analysis of the antiepileptic drug carbamazepine and five of its metabolites in human plasma has been developed. The analysis was carried out on a reversed-phase column (C8, 150x4.6 mm
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