69696
3-Hydroxycarbamazepine
analytical standard
别名:
3-OH-CBZ, 3-Hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
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关于此项目
经验公式（希尔记法）:
C15H12N2O2
化学文摘社编号:
分子量:
252.27
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
9204273
InChI key
QQCFBZCATDIWTH-UHFFFAOYSA-N
SMILES string
O=C(N)N1C(C=C(O)C=C2)=C2C=CC3=C1C=CC=C3
InChI
1S/C15H12N2O2/c16-15(19)17-13-4-2-1-3-10(13)5-6-11-7-8-12(18)9-14(11)17/h1-9,18H,(H2,16,19)
grade
analytical standard
assay
≥97.5% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
pharmaceutical
format
neat
storage temp.
2-8°C
Quality Level
General description
3-Hydroxycarbamazepine is a metabolite of carbamazepine, which is classified under the family of anticonvulsant drugs prevalently utilized for the therapeutic purpose. Carbamazepines occur abundantly in the environment and are suspected to cause potential threats to humans and wildlife.
Application
3-Hydroxycarbamazepine may be used as an analytical standard for the determination of the analyte in environmental samples, biological samples, water, sediment, fish (Gasterosteus aculeatus) and mollusk (Dreissena polymorpha) by various chromatography techniques.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
存储类别
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
R Mandrioli et al.
Journal of chromatography. B, Biomedical sciences and applications, 762(2), 109-116 (2001-10-27)
A high-performance liquid chromatographic method with UV detection for the simultaneous analysis of the antiepileptic drug carbamazepine and five of its metabolites in human plasma has been developed. The analysis was carried out on a reversed-phase column (C8, 150x4.6 mm
Gaëlle Daniele et al.
Environmental science and pollution research international, 24(20), 16893-16904 (2017-06-03)
The aims of this work are to develop suitable analytical methods to determine the widely used anticonvulsant carbamazepine and 12 of its degradation/transformation products in water, sediment, fish (Gasterosteus aculeatus) and mollusc (Dreissena polymorpha). Protocols based on solid phase extraction
Liquid chromatography-electrospray mass spectrometry determination of carbamazepine, oxcarbazepine and eight of their metabolites in human plasma
Breton H, et al.
Journal of Chromatography. B, Biomedical Applications, 828(1-2), 80-90 (2005)
P Pienimäki et al.
Journal of chromatography. B, Biomedical applications, 673(1), 97-105 (1995-11-03)
An HPLC assay for carbamazepine or oxcarbazepine (OXC) and six of their metabolites in one run was applied to 35 clinical samples from patients receiving monotherapy. This rapid and economical method, utilizing a simple one-step extraction with methyl tert.-butyl ether
Xiu-Sheng Miao et al.
Analytical chemistry, 75(15), 3731-3738 (2003-10-24)
A quantitative method is described for solid-phase extraction (SPE) followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the simultaneous analysis of carbamazepine and its five metabolites, 10,11-dihydro-10,11-epoxycarbamazepine, 10,11-dihydro-10,11-dihydroxycarbamazepine, 2-hydroxycarbamazepine, 3-hydroxycarbamazepine, and 10,11-dihydro-10-hydroxycarbamazepine. An SPE procedure was used to concentrate target
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