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等级
analytical standard
检测方案
≥98% (HPLC)
旋光性
[α]25/D -32.5 to -28.0°, c = 0.4 in H2O
保质期
limited shelf life, expiry date on the label
杂质
≤5.0% water
应用
clinical testing
格式
neat
SMILES字符串
N[C@@H](CC(=O)c1ccccc1N)C(O)=O
InChI
1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1
InChI key
YGPSJZOEDVAXAB-QMMMGPOBSA-N
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生化/生理作用
色氨酸降解途径的关键中间物。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Xue Jiang et al.
International journal of immunopathology and pharmacology, 34, 2058738420950584-2058738420950584 (2020-09-24)
Indoleamine 2,3-dioxygenase (IDO) was a potential tumor immunotherapy target. IDO inhibitors showed inconsistent results in clinical trials, but no preclinical comparative study was reported. The purpose of this study was to evaluate the differences of representative IDO inhibitors (PCC0208009, INCB024360
Ahmed Sadik et al.
Cell, 182(5), 1252-1270 (2020-08-21)
Aryl hydrocarbon receptor (AHR) activation by tryptophan (Trp) catabolites enhances tumor malignancy and suppresses anti-tumor immunity. The context specificity of AHR target genes has so far impeded systematic investigation of AHR activity and its upstream enzymes across human cancers. A
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