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Merck
CN

64306

Sigma-Aldrich

甲基硫代磺酸甲酯

purum, ≥98.0% (GC)

别名:

S-甲基硫代甲基砜, MMTS

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About This Item

线性分子式:
CH3SO2SCH3
CAS号:
分子量:
126.20
Beilstein:
1446059
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

等级

purum

质量水平

方案

≥98.0% (GC)

折射率

n20/D 1.513 (lit.)
n20/D 1.513

沸点

69-71 °C/0.4 mmHg (lit.)

溶解性

chloroform: 750mg + 5 ml Chloroform mg/mL, colorless to light greenish-yellow

密度

1.337 g/mL at 20 °C
1.337 g/mL at 25 °C (lit.)

官能团

disulfide

储存温度

2-8°C

SMILES字符串

CSS(C)(=O)=O

InChI

1S/C2H6O2S2/c1-5-6(2,3)4/h1-2H3

InChI key

XYONNSVDNIRXKZ-UHFFFAOYSA-N

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应用


  • 硫氢基酶的修饰:甲基硫代磺酸甲酯(MMTS)提供了一种修饰硫氢基酶和氧化还原调节蛋白的独特方法 ,提供了有关于酶调节和氧化还原生物学的生化研究中的潜在应用(Makarov et al., 2019)。

  • 用于蛋白酶活性的传感器开发: 甲基硫代磺酸甲酯被用作木瓜蛋白酶样半胱氨酸蛋白酶结构转化的阻滞剂,这有助于其在传感器开发中的用途,使我们可以检测和分析各种生物过程中的蛋白酶的活性(Markovic et al., 2023)。

  • 农业病原体控制:研究评估了作为晚期枯萎病抑制剂的甲基硫代磺酸甲酯,重点介绍了其作为植物病原体广泛毒素的潜力,暗示了其在农业农作物疾病管理中的应用(Joller et al., 2020)。

注意

储存时可能变为黄色

其他说明

亚甲基亚磺酰化剂有多种用途 ;对于 α-环酮的甲磺酰化 ;硫醇中的甲基二硫化物;酶的选择性、可逆性失活

储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(°F)

188.6 °F - closed cup

闪点(°C)

87 °C - closed cup

个人防护装备

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the solubility of Product 64306, S-Methyl methanethiosulfonate?

    Product 64306, S-Methyl methanethiosulfonate, is practically insoluble in water. It is soluble in methylene chloride. Several references do report that S-Methyl methanethiosulfonate is soluble in isopropanol at a 200mM concentration.  References are provided below: 1.  Yan, W., et al., "Quantitative Proteomic Analysis to Profile Dynamic Changes in the Spatial Distribution of Cellular Proteins", in Methods in Molecular Biology, Vol. 432: Organelle Proteomics, pp. 389-401 (Humana Press, 2008).2.  Sadowski, P.G., et al., Quantitative proteomic approach to study subcellular localization of membrane proteins.  Nature Protocols, 1, 1778-1789 (2006).

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

D. Scholz
Synthesis, 944-944 (1983)
P. Laszlo et al.
The Journal of Organic Chemistry, 49, 2281-2281 (1984)
Decha Enkvetchakul et al.
The Journal of general physiology, 130(3), 329-334 (2007-08-19)
Interactions between nontransmembrane domains and the lipid membrane are proposed to modulate activity of many ion channels. In Kir channels, the so-called "slide-helix" is proposed to interact with the lipid headgroups and control channel gating. We examined this possibility directly
Anna-Riikka Karala et al.
Antioxidants & redox signaling, 9(4), 527-531 (2007-02-07)
S-Methyl methanethiosulfonate (MMTS) is a reagent used to trap the natural thiol-disulfide state of the proteins. The efficiency of trapping mixed disulfides in vivo has been found to be higher for MMTS than for the more commonly used N-ethylmaleimide. MMTS
Vladimír Čermák et al.
Scientific data, 7(1), 160-160 (2020-05-29)
The plasticity of cancer cell invasion represents substantial hindrance for effective anti-metastatic therapy. To better understand the cancer cells' plasticity, we performed complex transcriptomic and proteomic profiling of HT1080 fibrosarcoma cells undergoing mesenchymal-amoeboid transition (MAT). As amoeboid migratory phenotype can

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