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安全信息

63013

Sigma-Aldrich

α2-巨球蛋白 来源于人类血浆

≥90% (GE)

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别名:
α2-M
CAS号:
1631137-21-7
MDL编号:
MFCD00130472
UNSPSC代码:
12352202
NACRES:
NA.61

生物来源

human plasma

质量水平

100

检测方案

≥90% (GE)

分子量

~720 kDa (four glycoprotein subunits)

技术

cell culture | mammalian: suitable

溶解性

H2O: 1 mg/mL, clear to faintly turbid, colorless to faintly yellow

UniProt登记号

P01023

运输

wet ice

储存温度

−20°C

基因信息

human ... A2M(2)

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应用

通过与蛋白酶形成复合物来抑制所有种类的内切蛋白酶。当蛋白酶切割巨球蛋白“诱饵”序列时，巨球蛋白重新排列并捕获蛋白酶。

生化/生理作用

α2-巨球蛋白在血浆和间质液中大量存在。蛋白酶-α2-M 平衡在介导炎症组织破坏中起重要作用。脓毒症、肺气肿、牙周炎、类风湿性关节炎和其他炎症性疾病患者的血清 α2-M 和蛋白酶-α2-M 复合物水平升高，而 α2-M 的氧化失活可能导致炎症期间的组织破坏。

分析说明

对每个供体的血浆都进行了检测，发现 HIV-1/HIV-2 抗体、HCV 抗体和 HbSAg 抗体均为阴性。
100 mg solids are lyophilized with 1 mg glycine from 35.2 mL 30 mM sodium phosphate, pH 7.0

其他说明

Conformational changes of α2-M

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品
常规特殊物品

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P A Roche et al.
Biochemistry, 28(19), 7629-7636 (1989-09-19)
Treatment of the human plasma proteinase inhibitor alpha 2-macroglobulin (alpha 2M) with proteinase results in conformational changes in the inhibitor and subsequent activation and cleavage of the internal thiolester bonds of alpha 2M. Previous studies from this laboratory have shown
Paul Dent et al.
Journal of cellular physiology, 235(10), 6862-6874 (2020-01-28)
We have extended our analyses of (curcumin+sildenafil) biology. The drug combination caused vascularization and degradation of mutant K-RAS that correlated with reduced phosphorylation of ERK1/2, AKT T308, mTORC1, mTORC2, ULK1 S757, STAT3, STAT5, and NFκB and increased phosphorylation of eIF2α
Yonathan Uriel et al.
Insect science, 27(2), 256-265 (2018-07-27)
We tested the recent hypothesis that the "fly factor" phenomenon (food currently or previously fed on by flies attracts more flies than the same type of food kept inaccessible to flies) is mediated by bacterial symbionts deposited with feces or
Alpha 2-macroglobulin.
H Ishibashi et al.
Methods in enzymology, 163, 485-495 (1988-01-01)
M Luo et al.
Journal of thrombosis and haemostasis : JTH, 15(12), 2451-2460 (2017-10-14)
Essentials Vitronectin (VN) is produced by smooth muscle cells (SMCs) and promotes neointima formation. We studied the regulation of vascular VN expression by plasminogen activator inhibitor-1 (PAI-1). PAI-1 stimulates VN gene expression in SMCs by binding LDL receptor-related protein 1.
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