61386
地奥司明
analytical standard
别名:
3′,5,7-三羟基-4′-甲氧基黄酮 7-芸香糖甙
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关于此项目
经验公式（希尔记法）:
C28H32O15
化学文摘社编号:
分子量:
608.54
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
85151701
EC Number:
208-289-7
MDL number:
InChI
1S/C28H32O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-8,10,19,21-30,32-37H,9H2,1-2H3/t10-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1
InChI key
GZSOSUNBTXMUFQ-YFAPSIMESA-N
SMILES string
COc1ccc(cc1O)C2=CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2
grade
analytical standard
assay
≥90% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
impurities
≤10% water
application(s)
food and beverages
format
neat
storage temp.
2-8°C
Quality Level
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General description
Diosmin is a flavonoid glycoside that occurs naturally as an active constituent of citrus fruits.(1) It possess a wide range of pharmacological properties like antioxidant, anticarcinogenic, blood-lipid lowering and also anti-inflammatory activities. Diosmin can also find applications in the healing of venous ulcers, enhancement of microcirculation and improvement of venous tone.
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Citrus flavonoid. Modification of hesperidin. Studied for its chemopreventive properties, including anti-proliferative and anti-inflammatory.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Other Notes
This compound is commonly found in plants of the genus: mentha
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Simultaneous reversed-phase high-performance liquid chromatographic method for the determination of diosmin, hesperidin and naringin in different citrus fruit juices and pharmaceutical formulations
Kanaze IF, et al.
Journal of Pharmaceutical and Biomedical Analysis, 33, 243-249 (2003)
Tran Duc Dung et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(5), 1802-1810 (2012-02-01)
Hepatocellular carcinoma is a common type of cancer with poor prognosis. This study examines the in vitro and in vivo mechanisms of diosmin on human hepato-cellular carcinoma HA22T cell proliferation inhibition. HA22T cells were treated with different diosmin concentrations and
Thangarasu Silambarasan et al.
European journal of pharmacology, 679(1-3), 81-89 (2012-01-24)
The present study was aimed to evaluate the antihypertensive effect of diosmin in deoxycorticosterone acetate (DOCA)-salt induced hypertension in male Wistar rats. Hypertension was induced in uninephrectomized rats by weekly twice subcutaneous injection of DOCA (25 mg/kg body weight) and
M Alcaraz et al.
Dento maxillo facial radiology, 40(5), 310-314 (2011-06-24)
The aim of this study was to evaluate the antioxidant substances present in the human diet with an antimutagenic protective capacity against genotoxic damage induced by exposure to X-rays in an attempt to reduce biological damage to as low a
Guy Lewin et al.
Journal of natural products, 76(1), 8-12 (2012-12-20)
Enhancement of the water solubility by disruption of molecular planarity has recently been reviewed as a feasible approach in small-molecule drug discovery programs. We applied this strategy to some natural flavone glycosides, especially diosmin, a highly insoluble citroflavonoid prescribed as
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