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经验公式(希尔记法):
C15H14N2O2
化学文摘社编号:
分子量:
254.28
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Beilstein/REAXYS Number:
1540211
MDL number:
SMILES string
N1(c2c(cccc2)C(Cc3c1cccc3)O)C(=O)N
InChI key
BMPDWHIDQYTSHX-UHFFFAOYSA-N
InChI
1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)
grade
analytical standard
assay
≥99% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Quality Level
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Application
10,11-二氢-10-羟基卡马西平可作为参比标准品,使用液相色谱法、 液相色谱串联质谱法 (LC-MS/MS) 和高效液相色谱串联紫外检测器 (HPLC-UV)测定生物样品中的 10,11-二氢-10-羟基卡马西平。
关于适当的仪器技术的更多信息,请参见产品的检验报告。联系技术服务部寻求进一步支持。
General description
10,11-二氢-10-羟基卡马西平是一种10-羟基衍生物,是奥卡西平的活性代谢产物。
10,11-二氢-10-羟基卡马西平是抗癫痫药物奥卡西平的活性代谢物。
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In this study, haptens were designed to produce highly sensitive and specific monoclonal antibodies (mAb) against carbamazepine (CBZ) and its metabolite carbamazepine-10, 11-epoxide (CBZ-EP). According to the results of our competitive enzyme-linked immunosorbent assay (ic-ELISA), the half-maximum inhibitory concentration values
First dose and steady-state pharmacokinetics of oxcarbazepine and its 10-hydroxy metabolite.
Dickinson R G, et al.
European Journal of Clinical Pharmacology, 37(1), 69-74 (1989)
Binding of licarbazepine enantiomers to mouse and human plasma proteins.
Fortuna A, et al.
Biopharmaceutics & Drug Disposition, 31(5-6), 362-366 (2010)
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