所有图片(1)
About This Item
经验公式（希尔记法）:
C8H4K2O12Sb2 · 3H2O
CAS号:
分子量:
667.87
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.21
等级
purum p.a.
质量水平
检测方案
99.0-103% (RT)
缺失
≤2.7% loss on drying
mp
≥300 °C (lit.)
痕量阴离子
chloride (Cl-): ≤100 mg/kg
sulfate (SO42-): ≤500 mg/kg
痕量阳离子
Ca: ≤50 mg/kg
Cd: ≤50 mg/kg
Co: ≤50 mg/kg
Cu: ≤50 mg/kg
Fe: ≤50 mg/kg
Na: ≤500 mg/kg
Ni: ≤50 mg/kg
Pb: ≤50 mg/kg
Zn: ≤50 mg/kg
SMILES字符串
O.O.O.[K+].[K+].O=C1O[Sb-]23OC1C4O[Sb-]5(OC(C(O2)C(=O)O3)C(=O)O5)OC4=O
InChI
1S/2C4H4O6.2K.3H2O.2Sb/c2*5-1(3(7)8)2(6)4(9)10;;;;;;;/h2*1-2H,(H,7,8)(H,9,10);;;3*1H2;;/q2*-2;2*+1;;;;2*+3/p-4
InChI key
WBTCZEPSIIFINA-UHFFFAOYSA-J
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一般描述
酒石酸锑钾三水合物是一种三价锑化合物。有报告称它是一种利什曼原虫化合物，并且与五价锑 (葡萄糖酸锑钠) 相比，对利什曼原虫显示出更大的毒性作用。 有报告称三维 X 线和白色辐射中子衍射方法曾用于研究其旋光体的晶体结构（二钾二-μ-d-酒石酸 (4)-双（锑酸盐 (III) 三水合物）。报告的晶胞尺寸为：a = 11.192 (2)、b = 11.696 (3) 和 c = 25.932(5)Å。
应用
酒石酸锑钾三水合物可用作含 Sb (III) 的药物，以研究其诱导与婴儿利什曼原虫 的无菌无鞭毛体 DNA 断裂相关的细胞死亡的能力。
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
危险化学品
D Sereno et al.
Antimicrobial agents and chemotherapy, 45(7), 2064-2069 (2001-06-16)
The basic treatment of leishmaniasis consists in the administration of pentavalent antimonials. The mechanisms that contribute to pentavalent antimonial toxicity against the intracellular stage of the parasite (i.e., amastigote) are still unknown. In this study, the combined use of several
D Sereno et al.
Antimicrobial agents and chemotherapy, 41(5), 972-976 (1997-05-01)
Using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide microassay, previously described as a means of quantifying Leishmania amazonensis in vitro at the amastigote stage (D. Sereno and J. L. Lemesre, Parisitol. Res., in press), we have compared the activities of seven drugs, including those
D Sereno et al.
Antimicrobial agents and chemotherapy, 42(12), 3097-3102 (1998-12-03)
The mechanism(s) of activity of pentavalent antimony [Sb(V)] is poorly understood. In a recent study, we have shown that potassium antimonyl tartrate, a trivalent antimonial [Sb(III)], was substantially more potent than Sb(V) against both promastigotes and axenically grown amastigotes of
Daniel B Liarte et al.
Parasitology research, 107(1), 205-212 (2010-04-08)
In the present study, we selected in vitro populations of Leishmania Viannia guyanensis, L.V. braziliensis, L. Leishmania amazonensis and L.L. infantum chagasi that were resistant to potassium antimony tartrate (SbIII). The resistance index of these populations varied from 4- to
Avijit Sarkar et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 79(1), 35-45 (2010-12-25)
Nitric oxide (NO) has been demonstrated to be a principal effector molecule responsible for mediating intracellular killing of Leishmania parasites, the causative organism of leishmaniasis. As measurement of intracellular NO remains a challenge to biologists, we have developed a flow
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