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Merck
CN

60063

酒石酸氧锑钾 三水合物

99.0-103% (RT), purum p.a.

别名:

吐酒石, 酒石酸钾锑 三水合物

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关于此项目

经验公式(希尔记法):
C8H4K2O12Sb2 · 3H2O
化学文摘社编号:
分子量:
667.87
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
234-293-3
MDL number:
Assay:
99.0-103% (RT)
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产品名称

酒石酸氧锑钾 三水合物, purum p.a., 99.0-103% (RT)

InChI

1S/2C4H4O6.2K.3H2O.2Sb/c2*5-1(3(7)8)2(6)4(9)10;;;;;;;/h2*1-2H,(H,7,8)(H,9,10);;;3*1H2;;/q2*-2;2*+1;;;;2*+3/p-4

InChI key

WBTCZEPSIIFINA-UHFFFAOYSA-J

SMILES string

O.O.O.[K+].[K+].O=C1O[Sb-]23OC1C4O[Sb-]5(OC(C(O2)C(=O)O3)C(=O)O5)OC4=O

grade

purum p.a.

assay

99.0-103% (RT)

loss

≤2.7% loss on drying

mp

≥300 °C (lit.)

anion traces

chloride (Cl-): ≤100 mg/kg
sulfate (SO42-): ≤500 mg/kg

cation traces

Ca: ≤50 mg/kg
Cd: ≤50 mg/kg
Co: ≤50 mg/kg
Cu: ≤50 mg/kg
Fe: ≤50 mg/kg
Na: ≤500 mg/kg
Ni: ≤50 mg/kg
Pb: ≤50 mg/kg
Zn: ≤50 mg/kg

Quality Level

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Application

酒石酸锑钾三水合物可用作含 Sb (III) 的药物,以研究其诱导与婴儿利什曼原虫 的无菌无鞭毛体 DNA 断裂相关的细胞死亡的能力。

General description

酒石酸锑钾三水合物是一种三价锑化合物。有报告称它是一种利什曼原虫化合物,并且与五价锑 (葡萄糖酸锑钠) 相比,对利什曼原虫显示出更大的毒性作用。 有报告称三维 X 线和白色辐射中子衍射方法曾用于研究其旋光体的晶体结构(二钾二-μ-d-酒石酸 (4)-双(锑酸盐 (III) 三水合物)。报告的晶胞尺寸为:a = 11.192 (2)、b = 11.696 (3) 和 c = 25.932(5)Å。

pictograms

Skull and crossbonesEnvironment

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

危险化学品
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历史批次信息供参考:

分析证书(COA)

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D Sereno et al.
Antimicrobial agents and chemotherapy, 45(7), 2064-2069 (2001-06-16)
The basic treatment of leishmaniasis consists in the administration of pentavalent antimonials. The mechanisms that contribute to pentavalent antimonial toxicity against the intracellular stage of the parasite (i.e., amastigote) are still unknown. In this study, the combined use of several
D Sereno et al.
Antimicrobial agents and chemotherapy, 41(5), 972-976 (1997-05-01)
Using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide microassay, previously described as a means of quantifying Leishmania amazonensis in vitro at the amastigote stage (D. Sereno and J. L. Lemesre, Parisitol. Res., in press), we have compared the activities of seven drugs, including those
X-ray and white radiation neutron diffraction studies of optically active potassium antimony tartrate, K2Sb2(dC4H2O6)2? 3H2O (tarter emetic).
Gress ME and Jacobson RA.
Inorgorganica Chimica Acta, 8, 209-217 (1974)
D Sereno et al.
Antimicrobial agents and chemotherapy, 42(12), 3097-3102 (1998-12-03)
The mechanism(s) of activity of pentavalent antimony [Sb(V)] is poorly understood. In a recent study, we have shown that potassium antimonyl tartrate, a trivalent antimonial [Sb(III)], was substantially more potent than Sb(V) against both promastigotes and axenically grown amastigotes of
K C Carter et al.
Parasitology, 131(Pt 6), 747-757 (2005-12-13)
Co-treatment of mice infected with different strains of Leishmania donovani with a non-ionic surfactant vesicle formulation of buthionine sulfoximine (BSO-NIV), and sodium stibogluconate (SSG), did not alter indicators of Th1 or Th2 responses but did result in a significant strain-independent

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