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Merck
CN

60063

Sigma-Aldrich

酒石酸氧锑钾 三水合物

purum p.a., 99.0-103% (RT)

别名:

吐酒石, 酒石酸钾锑 三水合物

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About This Item

经验公式(希尔记法):
C8H4K2O12Sb2 · 3H2O
CAS号:
分子量:
667.87
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.21
方案:
99.0-103% (RT)

等级

purum p.a.

质量水平

方案

99.0-103% (RT)

缺失

≤2.7% loss on drying

mp

≥300 °C (lit.)

痕量阴离子

chloride (Cl-): ≤100 mg/kg
sulfate (SO42-): ≤500 mg/kg

痕量阳离子

Ca: ≤50 mg/kg
Cd: ≤50 mg/kg
Co: ≤50 mg/kg
Cu: ≤50 mg/kg
Fe: ≤50 mg/kg
Na: ≤500 mg/kg
Ni: ≤50 mg/kg
Pb: ≤50 mg/kg
Zn: ≤50 mg/kg

SMILES字符串

O.O.O.[K+].[K+].O=C1O[Sb-]23OC1C4O[Sb-]5(OC(C(O2)C(=O)O3)C(=O)O5)OC4=O

InChI

1S/2C4H4O6.2K.3H2O.2Sb/c2*5-1(3(7)8)2(6)4(9)10;;;;;;;/h2*1-2H,(H,7,8)(H,9,10);;;3*1H2;;/q2*-2;2*+1;;;;2*+3/p-4

InChI key

WBTCZEPSIIFINA-UHFFFAOYSA-J

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一般描述

酒石酸锑钾三水合物是一种三价锑化合物。有报告称它是一种利什曼原虫化合物,并且与五价锑 (葡萄糖酸锑钠) 相比,对利什曼原虫显示出更大的毒性作用。 有报告称三维 X 线和白色辐射中子衍射方法曾用于研究其旋光体的晶体结构(二钾二-μ-d-酒石酸 (4)-双(锑酸盐 (III) 三水合物)。报告的晶胞尺寸为:a = 11.192 (2)、b = 11.696 (3) 和 c = 25.932(5)Å。

应用

酒石酸锑钾三水合物可用作含 Sb (III) 的药物,以研究其诱导与婴儿利什曼原虫 的无菌无鞭毛体 DNA 断裂相关的细胞死亡的能力。

象形图

Skull and crossbonesEnvironment

警示用语:

Danger

危险分类

Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

危险化学品

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分析证书(COA)

Lot/Batch Number

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D Sereno et al.
Antimicrobial agents and chemotherapy, 45(7), 2064-2069 (2001-06-16)
The basic treatment of leishmaniasis consists in the administration of pentavalent antimonials. The mechanisms that contribute to pentavalent antimonial toxicity against the intracellular stage of the parasite (i.e., amastigote) are still unknown. In this study, the combined use of several
D Sereno et al.
Antimicrobial agents and chemotherapy, 41(5), 972-976 (1997-05-01)
Using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide microassay, previously described as a means of quantifying Leishmania amazonensis in vitro at the amastigote stage (D. Sereno and J. L. Lemesre, Parisitol. Res., in press), we have compared the activities of seven drugs, including those
X-ray and white radiation neutron diffraction studies of optically active potassium antimony tartrate, K2Sb2(dC4H2O6)2? 3H2O (tarter emetic).
Gress ME and Jacobson RA.
Inorgorganica Chimica Acta, 8, 209-217 (1974)
D Sereno et al.
Antimicrobial agents and chemotherapy, 42(12), 3097-3102 (1998-12-03)
The mechanism(s) of activity of pentavalent antimony [Sb(V)] is poorly understood. In a recent study, we have shown that potassium antimonyl tartrate, a trivalent antimonial [Sb(III)], was substantially more potent than Sb(V) against both promastigotes and axenically grown amastigotes of
G Sudhandiran et al.
The Journal of biological chemistry, 278(27), 25120-25132 (2003-04-23)
The capability of the obligate intracellular parasites like Leishmania donovani to survive within the host cell parasitophorous vacuoles as nonmotile amastigotes determines disease pathogenesis, but the mechanism of elimination of the parasites from these vacuoles are not well understood. By

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