推荐产品
方案
≥80% (HPLC)
抗生素抗菌谱
Gram-positive bacteria
作用机制
cell membrane | interferes
储存温度
−20°C
SMILES字符串
C[C@@H]1CCC(=O)O[Ca]OC(=CC(=O)[C@@H](C)C[C@@H](C)C1)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]2CC[C@](C)(O2)[C@H]3CC[C@](C)(O3)[C@@H](C)O
InChI
1S/C41H72O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42;/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47);/q;+2/p-2/b13-11+,34-24-;/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+;/m1./s1
InChI key
WKRWUYKLUMMAKG-WYGBAUISSA-L
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生化/生理作用
比A23187更有效地作为Ca2+ 的移动离子载体的Ca2+ 离子载体;无荧光;用于研究Ca2+ 跨生物膜的运输;诱导胚胎皮层神经元凋亡变性。
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
其他说明
Nonfluorescent ionophoric antibiotic which exhibits a greater selectivity for Ca2+ over Mg2+ than does A23187
替代产品
The Journal of biological chemistry, 259(4), 2262-2267 (1984-02-25)
Changes in the concentration of free cytosolic Ca2+ [( Ca2+]i), membrane potential, and immunoreactive insulin release were measured in suspensions of RINm5F cells. [Ca2+]i was monitored with the intracellularly trapped fluorescent Ca2+ indicator quin 2. Changes in membrane potential were
Proceedings of the National Academy of Sciences of the United States of America, 81(5), 1416-1420 (1984-03-01)
The cytosolic concentration of free Ca2+ in bovine neutrophils was monitored by using the intracellular Ca2+ indicator quin2, 2-[[2-bis(acetylamino)-5-methylphenoxy]methyl-6-methoxy-8- bis(acetylamino)]quinoline. Neutrophils at rest have a cytosolic Ca2+ concentration of 85 +/- 5 nM, which in 2-4 min increases to 300-400
The Journal of biological chemistry, 253(17), 5892-5894 (1978-09-10)
The ionophorous properties of a new antibiotic, ionomycin, have been studied. It was found that the antibiotic is capable of extracting calcium ion from the bulk of an aqueous phase into an organic phase. The antibiotic also acts as a
PloS one, 9(5), e98151-e98151 (2014-05-24)
Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking. The contribution of Mst1 to Ag-specific immune responses and autoimmunity has not
European journal of immunology, 45(2), 480-491 (2014-11-11)
Anergic T cells can survive for long time periods passively in a hyporesponsive state without obvious active functions. Thus, the immunological reason for their maintenance is unclear. Here, we induced peptide-specific anergy in T cells from mice by coculturing these cells with
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