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Merck
CN

56480

Sigma-Aldrich

N-羟基丁二酰亚胺

≥97.0% (T), for peptide synthesis

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别名:
1-羟基-2,5-吡咯烷二酮, HOSu, NHS
经验公式(希尔记法):
C4H5NO3
CAS号:
分子量:
115.09
Beilstein:
113913
EC 号:
MDL编号:
UNSPSC代码:
12352005
PubChem化学物质编号:
NACRES:
NA.22

等级

purum

质量水平

检测方案

≥97.0% (T)

形式

solid

反应适用性

reaction type: Addition Reactions

mp

95-98 °C (lit.)
95-98 °C

应用

peptide synthesis

SMILES字符串

ON1C(=O)CCC1=O

InChI

1S/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2

InChI key

NQTADLQHYWFPDB-UHFFFAOYSA-N

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应用

N-羟基丁二酰亚胺(NHS)可以用于以下实验:
  • 合成N-琥珀星氩氨-3(2-吡啶二硫代)-酸酯,这是一种异双功能试剂,用于蛋白和蛋白偶联以及脂肪族硫醇插入蛋白。
  • 合成长链脂肪酸的NHS酯
  • NHS可以活化固定在钛表面的膦酸单层,用于结合蛋白。

其他说明

可能含有1-3%的丁二酸和或丁二酸酐

象形图

Corrosion

警示用语:

Danger

危险声明

危险分类

Eye Dam. 1 - Skin Irrit. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Protein thiolation and reversible protein-protein conjugation. N-Succinimidyl 3-(2-pyridyldithio) propionate, a new heterobifunctional reagent.
Carlsson J
The Biochemical Journal, 173(3), 723-723 (1978)
Synthesis of long-chain fatty acyl-CoA thioesters using N-hydroxysuccinimide esters.
Blecher M
Methods in Enzymology, 72, 404-408 (1981)
Phosphonic acid monolayers for binding of bioactive molecules to titanium surfaces.
Adden N
Langmuir, 22(19), 8197-8204 (2006)
Kengo Nishi et al.
The Journal of chemical physics, 137(22), 224903-224903 (2012-12-20)
We investigated the relationship between the elastic modulus, G and the reaction probability, p for polymer networks. First, we pointed out that the elastic modulus is expressed by G = {(fp∕2 - 1) + O((p - 1)(2))} Nk(B)T∕V (percolated network
Burcu Ayoglu et al.
EMBO molecular medicine, 6(7), 918-936 (2014-06-13)
Despite the recent progress in the broad-scaled analysis of proteins in body fluids, there is still a lack in protein profiling approaches for biomarkers of rare diseases. Scarcity of samples is the main obstacle hindering attempts to apply discovery driven

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