56448
花椒毒素
analytical standard
别名:
8-甲氧基补骨脂素, 8-MOP, 9-甲氧基呋喃 [3,2- g ] 苯并吡喃-7-酮, 甲氧沙林, 花椒毒内酯, 花椒毒素
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关于此项目
经验公式（希尔记法）:
C12H8O4
化学文摘社编号:
分子量:
216.19
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
EC Number:
206-066-9
Beilstein/REAXYS Number:
196453
MDL number:
产品名称
花椒毒素, analytical standard
SMILES string
COc1c2OC(=O)C=Cc2cc3ccoc13
InChI key
QXKHYNVANLEOEG-UHFFFAOYSA-N
InChI
1S/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3
grade
analytical standard
assay
≥98% (GC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
148-150 °C (lit.)
application(s)
cleaning products
cosmetics
food and beverages
personal care
format
neat
storage temp.
2-8°C
Quality Level
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Biochem/physiol Actions
8-甲氧基补骨脂素 (8-MOP) 加 A 波紫外线 (UVA) 辐射可诱导单加合物形成和 DNA 链间交联，因此可用于研究 DNA 修复和重组机制。培养的正常人黑素细胞经 8-甲氧基补骨脂素处理和 A 波紫外线 (UVA) 照射后形成 8-甲氧基补骨脂素-磷脂光加成产物，经二酰甘油取代后可在无细胞体系中激活蛋白激酶 C。8-MOP 是纯化重组细胞色素 P450 的灭活剂。它还可以通过抑制 [Ca2+] 的升高，而抑制从 P 物质激活的大鼠腹膜肥大细胞的 P 物质诱导型组胺释放。
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
General description
Xanthotoxin is an allelochemical or a phototoxic allomone mainly found in host plants of black swallowtail. It can have the tendency to induce tolerance towards Α-cypermethrin, a pyrethroid insecticide used for insects like Helicoverpa zea.
Other Notes
This compound is commonly found in plants of the genus: angelica carum pimpinella
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2 - Muta. 2 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
高风险级别生物产品--毒素类产品
此项目有
Molecular cloning and expression of CYP6B8: a xanthotoxin-inducible cytochrome P450 cDNA from Helicoverpa zea
Li X, et al.
Insect Biochemistry and Molecular Biology, 30, 75-84 (2000)
Shruti Chowdhari et al.
Journal of cellular physiology, 229(11), 1630-1638 (2014-03-13)
Psoriasis is a chronic inflammatory skin disorder mediated by cross-talk occurring between epidermal keratinocytes, dermal vascular cells and immunocytes. Literature reveals that Signal transducer and activator of transcription 3 (STAT3), a protein involved in transmitting extracellular signals to the nucleus
Katarzyna Borowska et al.
International journal of pharmaceutics, 426(1-2), 280-283 (2012-02-09)
In the present study we have assessed the ability of (PAMAM) dendrimers G3 and G4 to facilitate transdermal delivery of 8-methoxypsoralen (8-MOP) in vivo. In vitro study using Franz diffusion cell revealed an enhanced transdermal flux for 8-MOP in complex
Katarzyna Borowska et al.
International journal of pharmaceutics, 436(1-2), 764-770 (2012-08-14)
In this work, we have focused on 8-methoxypsoralene (8-MOP) complexed with G2.5 and G3.5 poly(amido amine) (PAMAM) dendrimers. The purpose of this study was to investigate the efficacy of half-generation G2.5 and G3.5 PAMAM dendrimers conjugated with 8-MOP for delivery
E Archier et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 26 Suppl 3, 11-21 (2012-05-26)
Oral 8-methoxypsoralen-UV-A (PUVA) and Narrowband UV-B (NB-UVB or UVB TL-01) are well established treatments for chronic plaque psoriasis but there is limited evidence regarding their respective efficacy. To prepare for evidence-based recommendations concerning the practical use of oral 8-methoxypsoralen-UV-A and
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