55513
精胺
analytical standard
别名:
N,N′-双(3-氨基丙基)-1,4-丁二胺, 精素, 肌胺, 肝胺
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关于此项目
线性分子式:
NH2(CH2)3NH(CH2)4NH(CH2)3NH2
化学文摘社编号:
分子量:
202.34
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-754-2
Beilstein/REAXYS Number:
1750791
MDL number:
产品名称
精胺, analytical standard
InChI key
PFNFFQXMRSDOHW-UHFFFAOYSA-N
InChI
1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
SMILES string
[H]N(CCCN)CCCCN([H])CCCN
grade
analytical standard
assay
≥99.0% (GC)
97.0-103.0% (T)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
impurities
≤0.5% carbonate
≤0.5% spermidine
bp
150 °C/5 mmHg (lit.)
mp
28-30 (lit.)
application(s)
cleaning products
cosmetics
food and beverages
personal care
format
neat
storage temp.
2-8°C
Quality Level
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Application
有关合适的仪器技术的更多信息，请参阅产品的分析证书。如需进一步支持，请联系技术服务。
Biochem/physiol Actions
多胺位点混合型 NMDA 受体激动剂/拮抗剂。在细胞增殖和分化中发挥作用；抑制神经元一氧化氮合成酶 (nNOS)。
多胺位点混合型 NMDA 谷氨酸受体激动剂/拮抗剂。在高浓度 (1mM) 下观察到神经保护作用，而在低浓度下则观察到神经毒性。它在番木鳖碱-不敏感性甘氨酸位点能够增强激动剂效应。在细胞增殖和分化中发挥作用；抑制神经元一氧化氮合成酶 (nNOS)。
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Wendy Wai Yeng Yeo et al.
Journal of nanoscience and nanotechnology, 14(5), 3328-3336 (2014-04-17)
A nano-sized polymer, dextran-spermine (D-SPM), was shown to have the capacity to deliver gene to the lung of mouse via intranasal route. In this study, assessments on the safety profile of D-SPM were performed to complement the gene expression results.
Yoshiyuki Kubo et al.
Experimental eye research, 124, 17-23 (2014-05-20)
The elimination of spermine, the end product of cellular polyamine, from the retina to the blood across the blood-retinal barrier (BRB) was investigated. The in vivo microdialysis study revealed that the elimination of [(3)H]spermine from vitreous humor after vitreous bolus injection
M Zhang et al.
Critical care medicine, 28(4 Suppl), N60-N66 (2000-05-12)
Spermine, a naturally occurring polyamine, is a ubiquitous structural component of all eukaryotic cells. Regenerating tissues produce higher levels of spermine, and injured or dying cells release spermine into the extracellular milieu, so that tissue levels increase significantly at inflammatory
R Amendola et al.
Current cancer drug targets, 9(2), 118-130 (2009-03-12)
The natural polyamines (PA), putrescine (PUT), spermidine (SPD) and spermine (SPM) are ubiquitous constituents of eukaryotic cells. The increase of PA in malignant and proliferating cells attracted the interest of scientists during last decades, addressing PA depletion as a new
Mg-ATP binding: its modification by spermine, the relevance to cytosolic Mg2+ buffering, changes in the intracellular ionized Mg2+ concentration and the estimation of Mg2+ by 31P-NMR.
D Lüthi et al.
Experimental physiology, 84(2), 231-252 (1999-05-05)
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